ISSN:
1432-0738
Keywords:
2,4-D-U 46 D Fluid
;
Molecular structure
;
Cytotoxicity
;
DNA strand breaks
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract U 46 D Fluid (the dimethylammonium salt of 2,4-dichlorophenoxyacetic acid in a commercial formulation) was more toxic to human fibroblasts than 2,4-dichlorophenoxyacetic acid (2,4-D). Moreover, U 46 D Fluid induced single-strand breaks at apurinic/apyrimidinic (AP) sites of heat-acid treated PM2 DNA while 2,4-D did not. The1H-NMR spectrum of the dimethylammonium (DMA) salt of 2,4-D indicated the formation of a complex via a six-membered aggregate of the DMA ion and the acid group of 2,4-D. The role of complex formation of the DMA salt of 2,4-D as a cause of single-strand breaking activity and increased cytotoxicity is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01977633
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