ISSN:
1432-2072
Keywords:
Morphine
;
Dopamine
;
Hyperactivity
;
D-1 receptor
;
SCH 23390
;
Mouse
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Administration of morphine HCl (20 mg/kg SC) to male C57B1/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00187265
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