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  • D-1 receptor  (1)
  • Hyperactivity  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 93 (1987), S. 401-402 
    ISSN: 1432-2072
    Keywords: Morphine ; Dopamine ; Hyperactivity ; D-1 receptor ; SCH 23390 ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Administration of morphine HCl (20 mg/kg SC) to male C57B1/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.
    Type of Medium: Electronic Resource
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