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  • dog  (2)
  • DAPI/actinomycin D  (1)
  • Diagnostik  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical and applied genetics 76 (1988), S. 45-53 
    ISSN: 1432-2242
    Keywords: Heterochromatin ; DAPI/actinomycin D ; Salmo gairdneri R. ; Salmo trutta fario L. ; Salvelinus fontinalis M.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The heterochromatins of rainbow trout (Salmo gairdneri R.), brown trout (Salmo trutta fario L.) and brook trout (Salvelinus fontinalis M.) were characterized by sequential chromomycin A3/distamycin A/DAPI (CDD) and DAPI/actinomycin D (DAPI/AmD) fluorescence. On most biarmed chromosomes, an equilocal localization of prominent DAPI/AmD positive, chromomycin A3 negative, AT-rich blocks at the centromeres were observed in all three species. Band karyotypes of the three species were established. In rainbow trout, several DAPI/AmD positive heterochromatin blocks behaved positive in a silver-staining method. Mitotic and interphase studies proved the presence of inter-individual NOR variation in brown trout. The NORs of brook trout were localized on chromosomes 5, 10, 14, 15 and 29.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Veterinary research communications 21 (1997), S. 369-373 
    ISSN: 1573-7446
    Keywords: adenoma ; circumanal gland ; dog ; gene ; mutation ; p53 ; tumours
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Highly conserved regions of the tumour suppressor gene p53, including the typical human tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were investigated in various canine neoplasms. A mutation CGG → TGG (arginine → tryptophan) was detected in codon 249 in an adenoma of the circumanal gland.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Veterinary research communications 23 (1999), S. 285-291 
    ISSN: 1573-7446
    Keywords: dog ; gene ; mammary gland ; mutation ; p53 ; skin ; tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exons 4 to 8 of the tumour suppressor gene p53 were analysed in 25 skin and 25 mammary tumours of 50 dogs. A 1 bp deletion (ACC→AC) was detected in codon 89 in exon 4 in a squamous cell carcinoma. A missense mutation CGC→CAC (arginine→histidine) was present in codon 162 in exon 5 in a mammary adenocarcinoma. Moreover, a silent mutation occurred in codon 103 (serine) of exon 4 in a mammary adenoma. The somatic nature of the three mutations was demonstrated.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 634-635 
    ISSN: 1435-2451
    Keywords: Pelvic fractures ; Diagnosis ; Therapy ; Beckenfrakturen ; Diagnostik ; Behandlung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Beckenfrakturen werden durch a. p.-Kompression, laterale Kompression oder Vertikalverschiebung verursacht. Die a. p.-Kompression benötigt nur die Standard-Röntgentechnik, da dorsale Bandanteile nicht zerrissen sind. Die Therapie ist einfach — SchluB des Bruches. Lateralkompressionen zeigen ventrale Frakturen and dorsale Bandzerreißungen. Die Elastizität des Beckens zeigt nicht immer die Ausdehnung der Verletzung. Aus diesem Grund sind CT-Untersuchungen notwendig. Die dorsale Stabilisierung hat den Vorrang. Scherkräfte verursachen Verschiebung and ausgedehnte Zerreißungen der Weichteile. Die Röntgendiagnose zeigt klare Verhältnisse — kein CT notwendig. Beckenfrakturen sind haufig Kombinationsverletzungen. Hier sind Beckeneingangs- and Beckenausgangsebenen sowie Streß-CT-Bilder zu verlangen. Wesentlichster Therapiebestandteil ist die dorsale Stabilisierung, ventral nach Olerud, dorsal mit Schrauben.
    Notes: Summary Pelvic fractures and disruptions are mostly caused by three main forces: anterior-posterior compression, lateral compression, and vertical shearing. Anterior-posterior compression can make use of standard X-ray techniques because the strong posterior ligaments are not involved. Therapy is quite simple — like closing an open book. Lateral compression causing a rotatory injury shows rami or acetabulum fractures combined with disruptions of the posterior sacroiliac ligament. The elastic recoil often does not indicate the extent of the injury — computed tomography is thus mandatory. Posterior reconstruction has priority. Shearing forces cause displacement of bone and gross disruption of soft tissue structures. Radiological diagnosis is clear and no further computed tomography is necessary. As most pelvic fractures are combination injuries, we need additional inlet and outlet views of the pelvic ring or stress computer tomograms. Treatment is stabilization of the posterior bone and ligament structures and, for handling an avulsed anterior sacroiliac ligament, Olerud's technique. The posterior complex is treated by two screws. Both-sided dislocations are handled with transverse long screws or plates.
    Type of Medium: Electronic Resource
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