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  • 1
    Digitale Medien
    Digitale Medien
    Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain (1994)
    Springer
    Molecular genetics and genomics 242 (1994), S. 649-652 
    Details
    ISSN: 1617-4623
    Schlagwort(e): α-Globin domain ; Hypersensitive sites ; Locus control region ; Chromatin structure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The distribution of DNase I hypersensitive sites upstream of the chicken α-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5–14.5 kb upstream of the π gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at −8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (−3 kb), still belongs to the domain of the α-globin genes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00283418
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Organization of specific DNA sequence elements in the region of the replication origin and matrix attachment site in the chicken α-globin gene domain (1992)
    Springer
    Molecular genetics and genomics 235 (1992), S. 381-388 
    Details
    ISSN: 1617-4623
    Schlagwort(e): Bent DNA ; DNA melting pattern ; Replication origin ; Matrix attachment site ; Globin genes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary The distribution of specific DNA sequence elements in a 2.9 kb HindIII fragment of chicken DNA containing the replication origin and the upstream matrix attachment site (MAR) of the α-globin gene domain was investigated. The fragment was shown to contain a CR1-type repetitive element and two stably bent DNA sequences. One of them colocalizes with the previously described MAR element and with the recognition site for a proliferating-cell-specific, DNA-binding protein. The melting pattern of a set of subfragments of the region proved to be non random. No correlation between the distribution of readily melting sequences and bent DNA was found. The possible importance of curved, low-melting and repetitive DNA sequences for the organization of the upstream boundary of the α-globin gene domain and the function of the replication origin is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00279384
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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