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  • 1
    Electronic Resource
    Electronic Resource
    Fine structure of the rabbit adrenal cortex and the effects of short-term ACTH administration (1979)
    Springer
    Cell & tissue research 201 (1979), S. 165-179 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Steroid release ; Rabbit ; Electron microscopy ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure of the rabbit adrenal cortex was investigated. The parenchymal cells display the ultrastructural features of steroid-producing cells, and also contain numerous electron-dense bodies frequently located near intercellular canaliculi, which open into the subendothelial space. Short-term ACTH-administration induced a noticeable decrease in the volume of the lipid compartment in the cells of all three cortical zones and a significant increase in the volume of dense bodies in the cells of zona fasciculata and zona reticularis. The hypothesis that these dense bodies are secretory granules is discussed in the light of biochemical evidence showing that ACTH increases the concentration of both corticosterone and cortisol in the decapsulated-enucleated adrenal homogenate and does not affect the activity of two lysosome-marker enzymes (i.e., acid phosphatase and β-glucuronidase).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235055
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1975)
    Springer
    Cell & tissue research 163 (1975), S. 273-290 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; Dexamethasone ; DNA-synthesis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of dexamethasone (for up to 15 consecutive days) on both the morphology and DNA-synthesis of the mitochondria of the rat adrenal zona fasciculata were investigated by stereologic and autoradiographic techniques. Up to the 3rd day of continuous dexamethasone treatment, the average volume of mitochondria did not change, whereas the number of mitochondria per cell was significantly decreased. From the 3rd to the 15th day of hormonal administration both the volume and number of mitochondria were found to decrease in proportion to the duration of treatment. Autoradiography showed that after the 3rd day of dexamethasone administration there is virtually no incorporation of 3H-thymidine into the mitochondrial compartment. These findings are discussed in the light of evidence indicating that dexamethasone blocks ACTH-release by inhibiting the hypothalamo-hypophyseal axis. The results confirm the view that ACTH controls the maintenance of growth and proliferation of rat adrenocortical mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219464
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1976)
    Springer
    Cell & tissue research 168 (1976), S. 1-9 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; ACTH ; Stereology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of ACTH (up to 36 consecutive days) on the mitochondria of the zona reticularis of the rat adrenal cortex were investigated by stereologic techniques. It was found that ACTH induces two phases of hypertrophy of mitochondria alternating with two proliferative stages, which are associated with a significant decrease in the average volume of the organelles. It is suggested that, as in the zona fasciculata, ACTH controls the processes of growth and division of mitochondria in the zona reticularis. The mechanism underlying this action of ACTH as well as the differences between the responses to ACTH of the mitochondrial population of the two adrenal zones are discussed in the light of evidence indicating that mitochondria contain a complete genetic apparatus largely independent of nuclear control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219719
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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