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  • 1
    Electronic Resource
    Electronic Resource
    Effects of prolonged dopamine infusion on the zona glomerulosa of sodium-restricted rats treated or not with prolactin: Stereology and plasma hormone concentrations (1988)
    Springer
    Research in experimental medicine 188 (1988), S. 209-216 
    Details
    ISSN: 1433-8580
    Keywords: Zona glomerulosa ; Dopaminergic system ; Prolactin ; Aldosterone ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prolonged sodium restriction was found to induce a notable hypertrophy of rat zona glomerulosa (ZG) cells and a significant rise in the basal plasma aldosterone concentration. Chronic prolactin administration significantly furthered the effects of sodium restriction. Dopamine infusion (3 mg/kg day for 7 days) did not apparently affect ZG morphology and function in the control rats, while it significantly counteracted the effects of sodium deprivation combined or not with prolactin administration. However, the action of dopamine was less intense in sodium-deprived rats treated with prolactin. These findings confirm the view [15] that the dopaminergic system exerts a tonic inhibitory effect, modulated by the sodium balance, on the growth and secretory activity or rat ZG. Moreover, they suggest that the mechanism(s) underlying the antiadrenoglomerulotrophic action of dopamine in rats only partially involve(s) the well-known suppression of the hypophyseal release of prolactin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852322
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Further studies on the effects of prolonged prolactin administration on the zona glomerulosa of the rat andrenal cortex (1986)
    Springer
    Research in experimental medicine 186 (1986), S. 307-315 
    Details
    ISSN: 1433-8580
    Keywords: Zona glomerulosa ; Prolactin ; Aldosterone ; Rat ; Stereology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of a prolonged treatment with prolactin on the morphology and hormone secretion of adrenal zona glomerulosa of gonadectomized testosterone-replaced rats were investigated by coupled morphometric and radioimmunologic techniques. The dexamethasone/captoprilinduced atrophy of zona glomerulosa cells (−42%) and fall in the blood level of aldosterone (−37%) were partially counteracted by chronic prolactin administration: the values had increased by about 15% and 17%, respectively, but remained lower than in the control animals. The prolonged treatment with prolactin of dexamethasone/captopril-administered ACTH/angiotensin II-replaced rats provoked a striking increase in the zona glomerulosa cell volume (24%) and in the blood level of aldosterone (33%) above the control values. The possibility is discussed whether prolactin may be directly involved in the stimulation of the growth and steroidogenic capacity of rat zona glomerulosa, without interacting with the gonads and interfering with the hypothalamo-hypophyseal axis and the renin-angiotensin system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852307
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Investigations on the turnover of adrenocortical mitochondria (1975)
    Springer
    Cell & tissue research 163 (1975), S. 273-290 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal cortex ; Mitochondria ; Dexamethasone ; DNA-synthesis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of chronic administration of dexamethasone (for up to 15 consecutive days) on both the morphology and DNA-synthesis of the mitochondria of the rat adrenal zona fasciculata were investigated by stereologic and autoradiographic techniques. Up to the 3rd day of continuous dexamethasone treatment, the average volume of mitochondria did not change, whereas the number of mitochondria per cell was significantly decreased. From the 3rd to the 15th day of hormonal administration both the volume and number of mitochondria were found to decrease in proportion to the duration of treatment. Autoradiography showed that after the 3rd day of dexamethasone administration there is virtually no incorporation of 3H-thymidine into the mitochondrial compartment. These findings are discussed in the light of evidence indicating that dexamethasone blocks ACTH-release by inhibiting the hypothalamo-hypophyseal axis. The results confirm the view that ACTH controls the maintenance of growth and proliferation of rat adrenocortical mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219464
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    Paper (German National Licenses)
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