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[d-Pen2,d-Pen5]enkephalin, the standard delta opioid agonist, induces morphine-like behaviors in mice (1990)

Murray, Christopher W. ; Cowan, Alan

Springer

Psychopharmacology 102 (1990), S. 425-426

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ISSN: 1432-2072

Keywords: DPDPE ; Straub tail ; Opioid receptor selectivity

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract [d-Pen2,d-Pen5]enkephalin (DPDPE; 3–30 µg) and morphine (10 µg) both caused Straub tails, increased locomotion, and circling after ICV administration to ICR mice. DPDPE-induced tail stiffening was reduced when mice were pretreated with naloxone (0.5 mg/kg SC) orβ-funaltrexamine (10 µg ICV), but not with ICI 174864 (2 mg/kg SC), the selective antagonist at delta opioid receptors. These results point to (a) mu receptors mediating the tail stiffening and (b) the loss of delta receptor selectivity after 10 and 30 µg DPDPE.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02244117

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