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  • 1
    Electronic Resource
    Electronic Resource
    Differential effects of chlordiazepoxide and d-amphetamine on responding maintained by a DRL schedule of reinforcement (1974)
    Springer
    Psychopharmacology 38 (1974), S. 159-171 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; d-Amphetamine ; DRL Responding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats pressed a lever and obtained food pellets on a schedule of differential reinforcement of low rate (DRL) which required that responses were spaced at least 15 sec apart in order for them to produce reinforcement. When responding had stabilised at slow and steady rates the effects of d-amphetamine and chlordiazepoxide were assessed. Low doses of both drugs increased response rates while higher doses decreased them. Reinforcement frequency showed a dose related decrease after both drugs. When interresponse times (IRTs) were analysed it was found that both drugs shifted the peak of the distribution towards shorter IRTs but that chlordiazepoxide also produced a specific increase in the percentage of responses after very short IRTs (bursts). When IRTs were divided into those following a reinforced response (hit) and those following a non-reinforced response (miss) it was found that bursts normally followed only misses and chlordiazepoxide consistently increased the number of bursts following misses only. Amphetamine did not affect bursts in any consistent way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426110
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of tranquillizing drugs on timing behaviour in rats (1975)
    Springer
    Psychopharmacology 44 (1975), S. 153-156 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Phenobarbitone ; Chlorpromazine ; DRL Responding ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Timing behaviour was generated in rats by a schedule which required responses to be spaced at least 15 sec apart in order for them to produce food reinforcement (DRL 15 sec). The behaviour maintained by this schedule was then studied after administration of chlordiazepoxide, phenobarbitone and chlorpromazine. Several doses of both chlordiazepoxide and phenobarbitone were found to disrupt timing behaviour by increasing overall response rates although the highest dose of each of these two drugs produced sedative effects. Chlorpromazine produced mainly a decrease in overall response rates. Analysis of performance in terms of interresponse times (IRTs) showed that both chlordiazepoxide and phenobarbitone markedly increased the percentage of IRTs less than 1.5 sec in duration (response bursts). Chlorpromazine had no consistent effect on response bursts. Reduction of the animals' body weights from 85% to 75% of their pre-experimental levels had no effect on operant performance, suggesting that the effects of the drugs were probably not due to actions on motivational processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421002
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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