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  • 1
    ISSN: 1432-2307
    Keywords: Endotoxin shock ; Lung ; Endotoxin-positive cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following an intravenous administration into rats of a shock-inducing dose of endotoxin (2 mg) the lipopolysaccharide (LPS) was demonstrated immunohistochemically (light and electron microscopy) and determined quantitatively (radio-labelled LPS) in the lung tissue and in isolated alveolar macrophages. At different times after LPS injection morphological investigations of the pulmonary tissue and alveolar macrophages were carried out. One hour after endotoxin treatment 3% of the alveolar macrophages were already LPS-positive. The maximum extent of the immunoperoxidase reaction for endotoxin (100% cells involved) was observed on day 3, the vast majority (98%) of the alveolar macrophages being LPS-positive still on day 14. 0.9% of the injected radio-labelled LPS preparation was found to be associated with lung tissue on day 3. By this time 0.173 µg LPS/106 alveolar macrophages was detected. During the time of ultrastructural investigation endotoxin appeared in the lung only within cells. By their high capacity for storing endotoxin and their numerical superiority the mononuclear phagocytes are the leading LPS-positive cells in the lung, although granulocytes, endothelial cells, and alveolar epithelial cells were sometimes also involved. The accumulation of a high percentage of activated macrophages in the lung seen in the late stage of shock could represent at least one of the main factors leading to damage of pulmonary tissue. The correlation between appearance of LPS-positive macrophages and histological signs of lung tissue injury in the present investigation is striking.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Theoretical chemistry accounts 104 (2000), S. 179-182 
    ISSN: 1432-2234
    Keywords: Key words: Isospectral Hamiltonians ; Darboux's transformation ; Molecular potentials ; Schroedinger equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract. A generalization of the Hulthén potential is presented on the basis of an approach that uses the factorization of a general Hamiltonian by means of a specific model of operational equations with the structure ∼β(r)∓(d/dr). To achieve this goal, the treatment of the V Hs(r) standard Hulthén potential for bound s states is carried out by proposing a particular βp(r) ansatz to identify V Hs(r) by means of a particular Riccati-type relationship. Once the identification has been achieved, the generalized Hulthén potential is obtained straightforwardly with the aid of a general Riccati formula. As expected, the Hamiltonian of the generalized Hulthén potential is isospectral when compared with the corresponding standard Hamiltonian. Moreover, according to the Darboux transform there exists a modified Hulthén potential which is also isospectral. We show that the latter is just a particular case of the generalized Hulthén interaction model.
    Type of Medium: Electronic Resource
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