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  • Dehydroascorbic acid  (1)
  • Fibroblasts  (1)
  • Glycosaminoglycans  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 230-232 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Ascorbic acid ; Dehydroascorbic acid ; Ascites cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effects of AA and DHA on ATP C+ cell multiplication in vitro were studied by measuring incorporation of 3H thymidine into DNA. The results obtained demonstrate that both AA and DHA have the same effects: they favor cell multiplication at low doses and inhibit it at high doses. Experiments carried out with serial doses of both these substances revealed that AA is more efficient in determining both stimulating and inhibiting effects. The lesser efficiency of DHA may be attributed to its limited stability in culture medium. Studies on the effect of high doses of AA and DHA added to the culture medium in single or fractionated doses revealed that fractionated administration is more efficient in inhibiting cell multiplication than single administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00402472
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Extracellular glycosaminoglycans (GAG) released by chick embryonic fibroblasts (1984)
    Springer
    Cell & tissue research 238 (1984), S. 241-245 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Glycosaminoglycans ; Fibroblasts ; Receptors ; Secretory cells ; Lectin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Administration of Concanavalin A (Con A) to cultured skin fibroblasts derived from chick embryos at two developmental stages produce variations in the relative concentration of individual glycosaminoglycan (GAG) secreted by the cells. This effect is different: at 7 days (increase of hyaluronic acid and dermatan sulphate and decrease of chondroitin sulphate) and at 14 days (dermatan sulphate is not detectable). All the cells bind the Con A specifically, but a different pattern of agglutination is present in fibroblasts of the two embryonic ages. Since Con A is well known to bind carbohydrate-containing surface proteins, the result suggests that the release of GAG by chick embryonic fibroblasts can be modulated by cell surface receptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00217295
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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