ISSN:
1432-0533
Keywords:
Demyelinative diseases
;
Lymphoid cells
;
B cells
;
Multiple sclerosis
;
Subacute sclerosing panencephalitis
;
Progressive multifocal leukoencephalopathy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In 32 cases of human neurological disorders, including 19 cases of Multiple Sclerosis, an analysis was performed on formalin fixed paraffin embedded brain tissue, by using fluorescein labelled antibodies and Nomarski optics. This method, which allows the reduction of technical artifarcts, permitted to establish the presence of intracytoplasmic immunoglobulin binding lymphoid cells with IgG and IgA, more rarely IgM, in the majority of the multiple sclerosis cases. This supports the theory of the intrathecal secretion of antibodies within the central nervous system but does not allow to explain the function of those B. Lymphocytes. The same immunological picture was found in Subacute Sclerosing Panencephalitis. On the contrary, it was different in Progressive Multifocal Leucoencephalopathy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00691958
Permalink
