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  • 1
    Digitale Medien
    Digitale Medien
    Effects of chronic ethanol consumption beginning at adolescence: increased numbers of dendritic spines on cortical pyramidal cells in the adulthood (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 528-532 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Dendritic spines ; Ethanol ; Synaptic overshoot
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To increase our understanding of the effects of chronic ethanol consumption beginning at adolescence, 25% ethanol in drinking water (v/v) was administered daily to young rats aged 45–50 days for 5 months. Increased numbers of dendritic spines on the apical dendrite of layer V pyramidal neurons of the somatosensory cortex (U-Mann-Whitney test,P〈0.01−0.05) were found in almost every 50-μm-long segment over a distance of 500 μm from the cell body in ethanol-treated rats at the age of 195–200 days when compared with age-matched controls. Although the mechanisms leading to this unusual finding are not know, it is suggested that impairment of the naturally occurring elimination of redundant synapses can not be ruled out.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687715
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  • 2
    Digitale Medien
    Digitale Medien
    Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 680-685 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Down's syndrome ; Alzheimer's disease ; Hippocampus ; Golgi method ; Dendritic spines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Samples of the hippocampus of four patients with Down's syndrome [two men aged 35 and 36 years with no evidence of Alzheimer's disease (AD) and two patients aged 47 and 55 years with associated AD] were obtained at post mortem and processed according to the rapid Golgi method. A significant reduction in the number of dendritic spines (DS) was found in the apical (middle, distal and oblique segments) and basilar (thick and thin segments) dendritic arbors of CA1 and CA2–3 pyramidal neurons in patients with Down's syndrome and no AD when compared to age-matched controls. An additional decrease of DS in every segment occurred in Down's patients with associated AD when compared to agematched controls and Down's patients with no AD. In Down's syndrome (either associated or not to AD) thin basilar dendrites were the most severely involved; in AD patients CA1 pyramids were more severely affected than pyramidal neurons of the CA2–3 subfield.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294247
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