Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Preferences for morphine in rats: Validation of an experimental model of dependence (1970)
    Springer
    Psychopharmacology 17 (1970), S. 137-150 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Dependence ; Withdrawal ; Self-Administration ; Delayed-Reinforcement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats were induced to administer morphine to themselves by drinking solutions of it in preference to water; this behaviour was found to be a valid model of morphine dependence. Previous “passive” medication with morphine was not necessary; initial aversions for the bitter morphine solutions were converted into preferences after the rats were repeatedly given only morphine solutions to drink in order to relieve thirst. The consumption of solutions of quinine which were initially equally aversive did not increase, suggesting that the repeated pairing of a bitter taste with relief of thirst did not account for the preferences for the morphine solutions. It appeared that the post-ingestional effects of morphine provided primary reinforcement for the rats; they were able to regulate their daily intake of the drug after being injected with varying doses of it and they lost weight abruptly during enforced abstinence. There was also evidence that the bitter taste of morphine had become a secondary reinforcer for rats with established preferences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402704
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Weight loss and shock-elicited aggression as indices of morphine abstinence in rats (1975)
    Springer
    Psychopharmacology 45 (1975), S. 157-161 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Naloxone ; Dependence ; Aggression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Weight loss and shock-elicited aggression have been compared as quantitative indices of morphine abstinence in rats. A range of doses of morphine was administered to rats by i.p. injection twice daily for 12–15 days. After injections were stopped, morphine-abstinent rats lost weight precipitously, and showed an increased frequency of fighting in response to aversive stimulation (foot-shock). Recovery of weight appeared complete after 15–20 days but a significant increase in aggression was found at 18 days post-withdrawal; this virtually disappeared after 52 days. Both the amount of weight lost and the frequency of fighting increased as a function of the previous maintenance dose of morphine; the effective dose range appeared similar for these two indices. Weight loss was much less variable than fighting, had the advantage of rapid, objective measurement, and appeared to be the more reliable index of abstinence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429054
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...