ISSN:
1432-2072
Keywords:
Electroconvulsive Shock Treatment
;
Serum Dopamine-Beta-Hydroxylase
;
Depression
;
Catecholamines
;
Sympathetic Nervous System
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Serum dopamine-beta-hydroxylase (DBH) activity was studied in unipolar and bipolar depressed patients who were free of medication and in normal controls. No significant difference was found. A second group of depressed patients were studied during a course of electroconvulsive shock treatment (ECT). A small, but significant, increase in DBH activity was found 5 min after a single modified convulsion, suggesting release of DBH into the circulation. Also a small, but significant, increase in the baseline level of DBH activity was found at the ninth treatment compared to the first treatment. A single electroconvulsive shock administered to rats produced a significant elevation of both plasma epinephrine and norepinephrine at 1 and 5 min post convulsion and a significant, but smaller, elevation of plasma DBH at 5 min post convulsion in adrenalectomized rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429418
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