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  • Desipramine  (1)
  • Discrimination index  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Differential haloperidol effect on two indices of fentanyl-saline discrimination (1977)
    Springer
    Psychopharmacology 53 (1977), S. 169-173 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Fentanyl ; Drug discrimination ; Narcotic cue ; Discrimination index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using a discrete-trial, two-lever, foodreward discrimination learning paradigm, we trained rats (n=6) to discriminate 0.04 mg/kg fentanyl (s.c. t-30′) from saline. Stimulus generalization experiments with an adequate dose range (0.01–0.04 mg/kg) of fentanyl revealed that the ED50 value for drug lever selection is 0.02 mg/kg, irrespective of whether the animals were pretreated (s.c., t-60′) with either saline or 0.08 mg/kg haloperidol. With increasing doses of the haloperidol-fentanyl combination, the percentage of total responding on the selected lever progressively decreased, and reached the 50% level at the highest drug combination. It is concluded that this percentage is heavily contaminated by factors unrelated to the discrimination condition being studied; these factors seem to invalidate this percentage as a discrimination index under experimental conditions (e.g., behaviorally toxic doses of drugs) where they are likely to operate. The use of response selection as a discrimination index in drug discrimination research is further argued.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426488
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Theoretical and methodological considerations on drug discrimination learning (1976)
    Springer
    Psychopharmacology 46 (1976), S. 169-177 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Cue ; State dependent learning ; Amphetamine ; Desipramine ; Haloperidol ; Chlordiazepoxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A method is described which allows the assessment of discriminative stimulus properties of drugs, and the ability of amphetamine (0.16 mg/kg, s.c), chlordiazepoxide (5 mg/kg, p.o.), desipramine (5 mg/kg, s.c), and haloperidol (0.02 mg/kg, s.c.) to produce a discriminative stimulus complex (DSC) is evidenced. The method is found to yield clear-cut data that are specifically related to drug discrimination learning without being possibly confounded by state dependent effects. In addition, the experimental procedure is designed so as to provide an appropriate measurement of operant response modulating drug effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421388
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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