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  • 1
    Electronic Resource
    Electronic Resource
    Myelin and myelinization in the telencephalon and mesencephalon of the lizard Gallotia galloti as revealed by the immunohistochemical localization of myelin basic protein (1992)
    Springer
    Anatomy and embryology 185 (1992), S. 475-487 
    Details
    ISSN: 1432-0568
    Keywords: Cortex ; Basal nuclei ; Mesencephalic nuclei ; Ontogenesis ; Phylogenesis ; Reptiles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have studied in the telencephalon and mesencephalon of the lizard Gallotia galloti the localization and the chronology of appearance of the immunoreactivity due to the presence of a myelin-specific protein: the Myelin Basic Protein (MBP). MBP-like immunoreactivity was present with different degrees of intensity in many nerve fibers (isolated, in tracts and in commissurae) and it was apparently more abundant in mesencephalon. During ontogeny the earliest MBP-like immunoreactivity was detected at E.36 in few tracts in mesencephalon and appeared at E.40 in telencephalon, proceeding caudo-rostrally and from the ventral (basal) to the dorsal (alar) regions. Accumulation of MBP continued after hatching. Oligodendrocyte cell bodies were not immunopositive, not even at the youngest ages studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174085
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  • 2
    Electronic Resource
    Electronic Resource
    Different effect of methylazoxymethanol on mouse cerebellar development depending on the age of injection (1985)
    Springer
    Experimental brain research 57 (1985), S. 279-285 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellum ; Development ; Methylazoxymethanol ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Methylazoxymethanol (MAM), a powerful antimitotic, has been extensively used to affect rodent CNS development. Here we show that MAM causes different effects on mouse cerebellum depending on the age of the injected pup. Sublethal doses were determined for each age. A single injection at birth permanently reduces the number of cells. In addition, the cytoarchitecture was greatly perturbed: Purkinje cells retained an immature aspect and were dispersed through the cerebellar cortex. A single dose of MAM injected into 5 day old mice also affected the number of cells but, at the level of light microscopy, the cytoarchitecture of the cerebellar cortex appeared not to be altered. Purkinje cells, however, showed some immaturity and degenerated around the 22nd postnatal day. This modulation of MAM effect appears to provide a good model for studying cerebellar ontogeny and neuronal plasticity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236533
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ectopic granule cell layer in mouse cerebellum after methyl-azoxy-methanol (MAM) treatment (1991)
    Springer
    Experimental brain research 86 (1991), S. 90-96 
    Details
    ISSN: 1432-1106
    Keywords: Development ; Immunohistochemistry ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Previous results from our laboratory (Bejar et al. 1985) indicated that a single injection in mouse pups of the antimitotic/mutagenic agent methylazoxymethanol at postnatal day 5 typically produces hypogranular cerebella with no changes in foliation, in contrast to the severe alterations observed after the more usual injection on the day of birth. Here we report that injection of a higher dose (30 mg/kg) of methylazoxymethanol, always at postnatal day 5, leads to the additional presence of a ectopic cell layer in adult cerebellum. Immunostaining with several antibodies recognizing cell specific proteins ruled out the possibility that these ectopic cells were glial and electron microscopy indicated that they were morphologically mature granule cells. In the molecular layer of other cerebellar areas and apparently unrelated with granule cell ectopia, ectopic Golgi epithelial cells were observed. The reason for the presence of these ectopic cells of different type in the molecular layer was discussed in relation with analogous ectopias obtained by other means.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00231043
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Release of [3H]l-glutamate and [3H]l-glutamine in rat cerebellum slices: A comparison of the effect of veratridine and electrical stimulation (1989)
    Springer
    Neurochemical research 14 (1989), S. 1053-1060 
    Details
    ISSN: 1573-6903
    Keywords: Glutamate ; alpha-ketoglutarate ; glutamine ; release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Depolarization-elicited release of neurotransmitter glutamate was studied in rat cerebellar slices previously loaded with either [3H]l-glutamate or [3H]l-glutamine. Both depolarization conditions used (e.g. long-lasting tonic depolarization elicited by veratridine, or short repetive electrical pulses) increased 6 to 8 folds the release of labelled glutamate and of another compound, presumably alpha-ketoglutarate, without modifying the release of labeled glutamine. Because of the position of the label in the precursor radioactive molecules, GABA was weakly labeled and aspartate was unlabeled. The properties of the evoked glutamate release from cerebellar slices were those of a neurotransmitter since it was inhibited by tetrodotoxin and was Ca2+-dependent. Alpha-ketoglutarate is either coreleased from nerve terminals or is released from astrocytes and could participate in glutamate recycling. The data confirm the generally accepted model implying the presence of two neurotransmitter glutamate pools, a neuronal pool of newly synthesized glutamate and an astrocytic storage pool, but in addition indicate that the former is in rapid isotopic equilibrium with the extracellular compartment. Our present results also indicate that the glutamate/glutamine cycle is not activated in depolarizing conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00965610
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    Paper (German National Licenses)
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