ISSN:
1432-2072
Keywords:
Phenylethanolamine N-methyltransferase
;
Epinephrine
;
Locomotor activity
;
Development
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract LY134046, a potent, selective inhibitor of rat brain phenylethanolamine N-methyltransferase, was shown to increase activity in 18- and 19-day-old rats. The effects on day 25 were different, with LY134046 causing a decrease in activity. The effects of yohimbine, a selective antagonist of the alpha-2 adrenergic receptor, were markedly different from LY134046, causing a decrease in activity on day 19. These data suggest that epinephrine synthesis may play an inhibitory role in the regulation of activity in young rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00444698
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