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  • Dextrorphan  (1)
  • Endorphins  (1)
  • Fentanyl  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Lack of evidence for a role of endorphinergic mechanisms in mediating a discriminative stimulus produced by diazepam in rats (1982)
    Springer
    Psychopharmacology 78 (1982), S. 282-284 
    Details
    ISSN: 1432-2072
    Keywords: Discriminative stimulus ; Diazepam ; Morphine ; Naloxone ; Endorphins ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male Sprague-Dawley rats were trained in a two-lever food-reinforced procedure to discriminate between the effect of saline and diazepam (2.5 mg/kg). After acquisition of this discrimination, the ability of morphine to generalize, and naloxone to antagonize the diazepam discriminative stimulus was tested. The rats did not generalized the effect of morphine, and naloxone did not antagonize the diazepam discriminative stimulus whether it was given prior or subsequent to diazepam. These data suggest a lack of involvement of endorphins in mediating the discriminative stimulus property of diazepam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428166
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects (1983)
    Springer
    Psychopharmacology 81 (1983), S. 224-227 
    Details
    ISSN: 1432-2072
    Keywords: Discriminative stimulus ; Fentanyl ; Morphine ; Ethanol ; Tetrahydropapaveroline ; Salsolinol ; 3-Carboxysalsolinol ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male Sprague-Dawley rats were trained in a two lever food-reinforced procedure to discriminate between the effects of saline and the synthetic narcotic analgestic fentanyl (0.04 mg/kg). After acquisition of this discrimination, generalization tests with morphine, ethanol and some tetrahydroisoquinoline alkaloids were conducted. The rats dose-dependently generalized the effect of morphine but did not generalize the effects of either ethanol, tetrahydropapaveroline, salsolinol or 3-carboxysalsolinol to the fentanyl discriminative stimulus. Thus, these data do not support a biochemical link between ethanol and opiates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427266
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of narcotic and non-narcotic drugs in rats trained to discriminate opiate ϰ-receptor agonists (1982)
    Springer
    Psychopharmacology 78 (1982), S. 63-66 
    Details
    ISSN: 1432-2072
    Keywords: Drug discrimination ; Ethylketocyclazocine ; Bremazocine ; Nalorphine ; Pentazocine ; Buprenorphine ; Etorphine ; Dextrorphan ; Phencyclidine ; Ketamine ; Haloperidol ; Diazepam ; Pentobarbital ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to evaluate the discriminative stimulus properties of some narcotic and nonnarcotic drugs in rats trained to discriminate the effect of the proposed opiate ϰ-receptor agonists ethylketocyclazocine and bremazocine. Male Sprague-Dawley rats were trained in a two-lever food-reinforced paradigm to discriminate between the effect of ethylketocyclazocine (0.32 mg/kg) or bremazocine (0.04 mg/kg) and saline. Both groups of trained rats showed dose-dependent generalization to the effect of the proposed ϰ-agonist MRZ-2033 and some animals generalized the effect of nalophine and pentazocine. Some ethylketocyclazocine — but no bremazocine — trained rats generalized the effect of buprenorphine. The effect of dextrorphan, phencyclidine, and ketamine was generalized by some bremazocine-, but no ethylketocyclazocine-trained rats. Neither group of rats generalized the effect of etorphine, haloperidol, diazepam, or pentobarbital. These data suggest the usefulness of this procedure to evaluate the ϰ-like properties of opioid drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470590
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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