ISSN:
1432-0533
Keywords:
Streptozotocin
;
Peripheral neuropathy
;
Teased fiber
;
Diabetes
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An experimental diabetic state was induced in rats by means of an injection of streptozotocin. A histological and histometric evaluation of randomly teased nerve fibers was applied to the common peroneal nerves of both diabetic and age- and weight-matched control rats. A long-term (6–12 months) exposure to the diabetic state was required for the demonstration of the following morphological changes: (1) splitting and notching of myelin sheaths, (2) decrease in the ratio of internodal length/internodal diameter, (3) widening of nodal gaps. This study showed that neurons of smaller caliber are preferentially affected after a prolonged period of the diabetic condition. Neurons of this size are reprsentative of sensory and autonomic components, suggesting that the changes present in this model parallel the derangements of these constitutents reported in the human diabetic with adult onset disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00691599
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