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  • Diabetic heart muscle disease  (2)
  • Type 2 (non-insulin-dependent) diabetes  (2)
  • Diabetes mellitus  (1)
  • Myocardial metabolism  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Impairment of diastolic function in middle-aged Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients free of cardiovascular disease (1988)
    Springer
    Diabetologia 31 (1988), S. 783-791 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic heart muscle disease ; diabetic cardiomyopathy ; diastolic function ; autonomic neuropathy ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Left ventricular systolic and diastolic function was studied using systolic time intervals and echocardiography in 19 male and 17 female patients with Type 1 (insulin-dependent) diabetes, 24 male and 15 female patients with Type 2 (non-insulin-dependent) diabetes and 24 male and 24 female control subjects. The subjects for the present study were selected from a population based study in which 117 Type 1 and 510 Type 2 diabetic patients and 649 non-diabetic subjects were originally examined. After exclusions, none of the subjects had any evidence of coronary heart disease, hypertension or other diseases known to affect left ventricular function. There were no consistent differences in systolic time intervals or echocardiographic variables of systolic function between patients with Type 1 diabetes and non-diabetic control subjects; but patients with Type 2 diabetes showed an increased fractional shortening. Female patients with Type 2 diabetes showed an increased left ventricular mass not explicable by hypertension. Isovolumic relaxation period was longer in male (86±3 ms; mean±SEM) and female patients (84±6 ms) with Type 2 diabetes than in male (76±3 ms; p〈0.05) and female (71±3 ms; p〈0.05) control subjects. Peak diastolic filling rate was lower in female patients with Type 1 diabetes (12.8±0.8 cm/s, p〈0.05) and in male (11.5±0.8 cm/s; p〈0.01) and female patients (11.5±0.6 cm/s; p〈0.001) with Type 2 diabetes as compared to male (14.4±0.7 cm/s) and female (14.9±0.5 cm/s) control subjects. In male patients with Type 1 diabetes the respective value (12.7±0.6 cm/s) did not differ significantly from that in male control subjects. Altogether 14 diabetic patients (26%) showed an abnormal low peak diastolic filling rate. The impaired diastolic filling among diabetic patients did not show any relationship to the duration and metabolic control of diabetes or the presence of microangiopathy, but a weak correlation was found between the peak diastolic filling rate and the diminution of heart rate variation suggestive of the presence of diabetic autonomic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00277478
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Microalbuminuria predicts the development of serum lipoprotein abnormalities favouring atherogenesis in newly diagnosed type 2 (non-insulin-dependent) diabetic patients (1990)
    Springer
    Diabetologia 33 (1990), S. 237-243 
    Details
    ISSN: 1432-0428
    Keywords: Microalbuminuria ; serum lipids ; lipoproteins ; Type 2 (non-insulin-dependent) diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the relationship of slight albuminuria (microalbuminuria) to serum lipid and lipoproteins in a representative group of middle-aged Type 2 (non-insulin-dependent) diabetic patients. A random sample of non-diabetic control subjects was also examined. Diabetic patients had both at diagnosis and after five years higher total, LDL- and VLDL-triglyceride levels and higher VLDL-cholesterol, but lower HDL-cholesterol levels than non-diabetic subjects. No consistent difference was found in LDL-cholesterol levels between diabetic and non-diabetic subjects. The prevalence of microalbuminuria (〉35 mg/24 h) remained about the same in diabetic patients at both examinations (19–20%). The diabetic patients with persistent microalbuminuria were slightly hyperglycaemic and they tended to have lower creatinine clearance at the 5-year examination than those without persistent microalbuminuria. There were no differences in the blood pressure levels or the occurrence of hypertension between the diabetic groups with and without microalbuminuria. At the baseline examination, no differences were seen in serum lipids and lipoproteins between diabetic patients with and without microalbuminuria. In patients with persistent microalbuminuria. a statistically significant increase in VLDL-cholesterol (p〈0.05) and VLDL- and LDL-triglyceride levels (p〈0.05) and a decrease in HDL-cholesterol level (p〈0.05) was seen at the 5-year follow-up. These changes could not be explained by age, sex, body mass index or HbA1. In conclusion, persistent microalbuminuria predicts and aggravates abnormalities in lipoprotein composition and a decrease in HDL-cholesterol in patients with Type 2 diabetes mellitus. The excess cardiovascular morbidity and mortality in diabetic patients with increased albuminuria may, in part, be explained by these lipoprotein abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404802
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship between postheparin plasma lipases and high-density lipoprotein cholesterol in different types of diabetes (1987)
    Springer
    Diabetologia 30 (1987), S. 703-706 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes ; Type 2 (non-insulin-dependent) diabetes ; HDL cholesterol ; lipoprotein lipase ; hepatic lipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We measured serum lipids, lipoproteins and postheparin plasma lipases, lipoprotein lipase and hepatic lipase, in 12 female patients with Type 1 (insulin-dependent) diabetes (postglucagon C-peptide undetectable), in 11 female insulin-treated patients with Type 2 (non-insulin-dependent) diabetes (postglucagon C-peptide 〉0.60 nmol/l) and in 16 non-diabetic female control subjects. These three groups of subjects were similar with respect to age and obesity. Insulin dose was similar in patients with Type 1 and with Type 2 diabetes. HDL and HDL2 cholesterol were lower in patients with Type 2 diabetes than in non-diabetic control subjects (p〈0.05) but did not differ between patients with Type 1 diabetes and non-diabetic control subjects. No difference in lipoprotein lipase activity was seen between the groups. The highest levels of lipoprotein lipase and hepatic lipase activities were observed in patients with Type 2 diabetes. Lipoprotein lipase activity correlated significantly with HDL cholesterol in patients with Type 1 diabetes (p〈0.01) and in patients with Type 2 diabetes (p〈0.001) but not in control subjects. Hepatic lipase activity did not correlate significantly with HDL cholesterol in any of the groups. In conclusion, postheparin plasma lipoprotein lipase and hepatic lipase activities do not seem to explain the difference in HDL cholesterol concentration between patients with Type 1 and Type 2 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296992
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 475-481 
    Details
    ISSN: 1619-7089
    Keywords: Diabetic heart muscle disease ; Diabetes mellitus ; Free fatty acids ; Myocardial metabolism ; Radionuclide methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Myocardial free fatty acid metabolism and left ventricular function were evaluated in 15 middle-aged patients with non-insulin-dependent diabetes mellitus (NIDDM) and in 8 healthy control subjects. The study subjects had no evidence of coronary heart disease on the basis of clinical history, exercise ECG or myocardial perfusion scintigraphy. During peak exercise, iodine-123 hepatadecanoic acid (HDA) was intravenously injected. Myocardial activity distribution of 123I-HDA was measured 10, 30, and 50 min after exercise using single-photon emission tomography (SPET); and then further corrected by free 123I-iodine. Venous blood samples were drawn for detecting the plasma activity of 123I. The net extraction of 123I-HDA into the myocardium was obtained by dividing the corrected tissue 123I concentration by the integral of the plasma time activity curve. The net extraction was 0.40 ± 0.06 min−1 (mean ± SD) patients with NIDDM and 0.38 ± 0.06 min−1 in control subjects (P〉0.1), respectively. The faster elimination rate of 123I-HDA was found in patients with NIDDM (0.029±0.008 min−1) than in control subjects (0.022±0.004 min−1; P〈0.01). There was no statistically significant difference in left ventricular ejection fraction (LVEF) at rest between patients with NIDDM (53±9%) and control subjects (56±2%), whereas the increase of LVEF during exercise remained lower in patients with NIDDM (3.4±8.2%) than in control subjects (11.8±5.8%; P〈0.025). A significant correlation (r=0.64; P 〈 0.01) was found between the net extraction of 123I-HDA and the change of LVEF, as well as with exercise load (r=0.68; P〈0.01). In conclusion, evidence of an increased fatty acid utilization and triglyceride synthesis rate was observed in the diabetic myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181286
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    Paper (German National Licenses)
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