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  • 1
    Electronic Resource
    Electronic Resource
    Two opposite effects of diazepam on fear by differential training in the CER-paradigm (1981)
    Springer
    Psychopharmacology 75 (1981), S. 110-113 
    Details
    ISSN: 1432-2072
    Keywords: Diazepam ; CER paradigm ; Rats ; Discriminative stimulus complex (DSC) ; Anxiolytic effects ; Anxiogenic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two groups of rats were trained in a CER paradigm. The conditioned stimulus was a sound, the unconditioned stimulus was an electric shock. Group 1 received conventional CER training before the effects of different doses of diazepam were studied. For Group 2 the shock was always and exclusively given contingent on pretreatment with diazepam. After prolonged training the compound thus became a discriminative stimulus complex (DSC) and produced response suppression during the CS. Group 2 was also challenged with various doses of diazepam. The results showed that diazepam acquired diametrically different properties in the two groups. Group 1 exhibited disinhibitory effects and Group 2 suppressive effects, which may reflect anxiolytic and anxiogenic properties, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432170
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acute tolerance to amphetamine in rats (1976)
    Springer
    Psychopharmacology 49 (1976), S. 113-115 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Body temperature ; Food intake ; Motor behavior ; Stereotyped behavior ; Drug dependence ; Tolerance ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two groups of rats were given amphetamine intravenously at 5-min intervals (5 or 10 mg/kg/h) for 8h. Two control groups received saline infusions. On the second day a test dose of 10 mg/kg amphetamine was given to all groups. Body temperature, food intake, and motor behavior were registered every 30 or 60 min. The results showed the development of acute tolerance to the hyperthermic effect within 3–5 h. Tolerance was still visible on the 2nd day. There was also tolerance to the anorectic effect, which was evident on the 2nd day. One element of stereotyped behavior (swaying) also decreased during the amphetamine infusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427481
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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