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  • 1
    Electronic Resource
    Electronic Resource
    Temporäre Amaurose nach Kraniopharyngeomoperation (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 1067-1069 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Kraniopharyngeom ; Amaurose ; Chiasma ; Hormone ; Operation ; Key words Kraniopharyngioma ; Blindness ; Chiasma ; Endocrine dysfunction ; Surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Craniopharyngiomas are the third frequent pediatric brain tumors. Complications after surgical treatment are common. The most frequent complications are endocrine disturbances, vision field defects, deteriorated acuity, cognitive or psychological deficiency as well as significant weight gain. A case of complete vision loss right after surgical removal of craniopharyngioma is reported. Magnetic resonance image showed an edema of the chiasm. No damage of anatomical structure could be detected. Seventeen days after surgery the patient reported intermittent visual impressions for the first time. Over the following weeks his visus improved to 0.5, while the chiasm edema disappeared. Discussion: Even weeks after surgery-induced blindness regeneration of sufficient visus is possible.
    Notes: Zusammenfassung Das Kraniopharyngeom ist der dritthäufigste Hirntumor des Kindesalters. Komplikationen nach Kraniopharyngeomoperationen sind häufig. Zu den häufigsten Komplikationen zählen endokrine Störungen, Visusverschlechterung, Gesichtsfeldausfälle, emotionale und kognitive Veränderungen sowie Gewichtszunahme. Wir berichten über 1 Patientin, bei der unmittelbar nach der Operation eines Kraniopharyngeoms eine vollständige Amaurose auftrat. Bei intakten anatomischen Strukturen zeigte das MRT eine Ödem im Bereich des Chiasmas. 17 Tage nach der Operation traten erstmals wieder Seheindrücke auf, die sich im Verlauf von 6 Wochen bis zu einem Visus von 0,5 steigerten. Parallel dazu wies die Bildgebung einen Rückgang des Chiasmaödems auf. Diskussion: Auch Wochen nach einer eingetretenen operationsbedingten Amaurose kann bei intakten anatomischen Strukturen mit der Wiedererlangung eines ausreichenden Visus gerechnet werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050366
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Therapy of complex I deficiency: Peripheral neuropathy during dichloroacetate therapy (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 928-932 
    Details
    ISSN: 1432-1076
    Keywords: Complex I deficiency ; Polyvitamin therapy ; Dichloroacetate therapy ; Polyneuropathy ; Thiamine administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A therapeutic trial with polyvitamins and dichloroacetate (DCA) in combination with thiamine in a 13-year-old girl with complex I deficiency is reported. The polyvitamin therapy included thiamine, riboflavin, ascorbate, coenzyme Q 10 and carnitine. This therapeutic regine was used over a period of 17 months without any effect. Although DCA lowered the lactate concentration in blood and CNS — measured by magnetic resonance spectroscopy — no clinical benefit was achieved. After 20 weeks of DCA therapy a distal polyneuropathy with areflexia developed although 100 mg thiamine daily as comedication was given from the beginning of DCA therapy. Nerve conduction velocity of the peroneal nerve was not detectable, sensible evoked potentials of the tibialis posterious nerve were normal. This side-effect resolved completely within 6 months after omission of DCA. Our observation suggests a direct toxic effect of DCA only on the peripheral nervous system in our patient since several cerebral MRI and magnetic resonance spectroscopy studies showed no abnormalities. Conclusion DCA lowers the lactate concentration in children with complex I deficiency of the respiratory chain in a dose of 100 mg/kg body weight without clinical benefit. Reversible peripheral polyneuropathy may develop under DCA therapy despite thiamine medication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957508
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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