ISSN:
1573-739X
Keywords:
Biochemistry
;
Didanosine
;
Drug evaluation
;
Pharmacokinetics
;
Pharmacology
;
Side effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract In this article the literature about didanosine, an antiretroviral drug, is reviewed. The mechanism of action, biochemical pharmacology, pharmacokinetics, and clinical results of phase-I trials are discussed. Serious adverse effects such as pancreatitis and peripheral neuropathy have occurred in these trials. An antiretroviral effect was observed in terms of an increase in CD4+ lymphocytes and a decrease in p24 antigen levels in HIV-infected individuals. Didanosine seems to be a promising drug against HIV infection, but knowledge about its clinical efficacy is scanty.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01977617
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