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Diffusion-weighted MRI for monitoring neurovascular interventions (2000)

Lövblad, K. O. ; Plüschke, W. ; Remonda, L. ; [et al.]

Springer

Neuroradiology 42 (2000), S. 134-138

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ISSN: 1432-1920

Keywords: Key words Magnetic resonance imaging ; Diffusion-weighted ; Carotid artery ; Stents ; Carotid stenosis ; Angioplasty

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Carotid stenting is increasingly considered as treatment for carotid artery disease. A reliable noninvasive method is desirable for assessing the safety of the procedure. Diffusion-weighted MRI (DWI) is sensitive to early brain ischaemia which becoming widely available and might therefore serve this purpose. We prospectively studied 19 patients referred for investigation of carotid artery disease by echo-planar whole-brain DWI before and within 24 h of stenting. The images obtained at a high b value were examined by two independent blinded reviewers for new high-signal areas consistent with ischaemia. We found that 15 patients had no new changes after stenting. One patient showed enlargement of a posterior watershed lesion after the procedure, which correlated with an increase in neurological deficit. Three other patients had presumed small embolic infarcts on DWI; two were asymptomatic and one had weakness at the hand that corresponded to an embolic infarct with a lesion on DWI in the hand notch. There were no false- positive or -negative results on DWI, when compared to clinical findings. DWI is thus a new method that can demonstrate neurologically silent or asymptomatic infants. It can be used to help to assess the safety and efficacy of neurovascular intervention.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002340050032

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Determination of intraparticle immobilized enzyme distribution under moderate diffusion conditions (1992)

Hossain, Md. M. ; Do, D. D.

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 40 (1992), S. 743-747

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ISSN: 0006-3592

Keywords: immobilized enzyme ; active enzyme ; diffusion ; controlled-pore glass ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: The method Presented earlier by Hossain and Do determine the active enzyme distribution and relevant rate parameters under the condition of strong diffusional resistance is extended in this article to cover the cases of comparable diffusion and reaction rates (3 〈 φ 〈 20). The theory proposed herein is tested wtih the experimental data of hydrogen perioxide-catalase immobilized on controlled-pore glass (CPG) particles of small size (150 μm). © 1992 John Wiley & Sons, Inc.

Additional Material: 2 Ill.