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  • 1
    Electronic Resource
    Electronic Resource
    Peroxisomal oxidative capacity of brown adipose tissue depends on the thyroid status
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 61 (1989), S. 217-225 
    Details
    ISSN: 0303-7207
    Keywords: Brown adipose tissue ; Mitochondria ; Nafenopin ; Oxygen consumption ; Peroxisome ; Thyroid status ; β-Oxidation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(89)90133-0
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  • 2
    Electronic Resource
    Electronic Resource
    Impaired metabolic response to nerve stimulation in brown adipose tissue of hypothyroid rats
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 25 (1982), S. 213-226 
    Details
    ISSN: 0303-7207
    Keywords: (-)-[^3H]dihydro-alprenolol binding ; brown adipose tissue ; nerve stimulation ; thyroid hormone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(82)90054-5
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased guanine nuleotide binding and reduced equivalent production by brown adipose tissue in hypothalamic obesity - Recovery after cold acclimation
    Amsterdam : Elsevier
    FEBS Letters 146 (1982), S. 161-164 
    Details
    ISSN: 0014-5793
    Keywords: Adrenergic (β-) receptor ; Brown adipose tissue ; Cold acclimation ; Guanine nucleotide binding ; Hypothalamic obese rats ; Reduced equivalent
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(82)80726-6
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  • 4
    Electronic Resource
    Electronic Resource
    Modulation of β-oxidation and proton conductance pathway of brown adipose tissue in hypo- and hyperinsulinemic states
    Amsterdam : Elsevier
    FEBS Letters 166 (1984), S. 141-145 
    Details
    ISSN: 0014-5793
    Keywords: 32 000 M"r protein ; Brown adipose tissue ; Guanine nucleotide binding ; Mitochondria ; Reduced equivalent ; β-Oxidation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(84)80060-5
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    α-Aminoisobutyric acid uptake by cultured beating heart cells
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 255 (1972), S. 462-478 
    Details
    ISSN: 0005-2736
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(72)90150-2
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  • 6
    Electronic Resource
    Electronic Resource
    A comparative study of the effects of norepinephrine and vasopressin on Na transport and O2 consumption in frog skin (1976)
    Springer
    Pflügers Archiv 363 (1976), S. 187-191 
    Details
    ISSN: 1432-2013
    Keywords: Frog skin ; Sodium transport ; Oxygen consumption ; Catecholamines ; Vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experiments were designed to compare the effects of two hormones-vasopressin and norepinephrine-on the energetics of Na transport in frog skin. Simultaneous measurements of O2 consumption and net Na flux were performed in the same skins by means of O2 cathodes and the short circuit current technique. The results showed that both hormones induced similar increments in Na transport. In contrast, there was a conspicuous difference in O2 consumption values, norepinephrine having a very small stimulatory effect compared to the one induced by vasopressin. Thus, despite the fact that both hormones increase Na permeability of frog skin by similar mechanisms and to a similar extent, they appear to exert very different effects on cell metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594600
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  • 7
    Electronic Resource
    Electronic Resource
    Quantitative evaluation of gap junctions in rat brown adipose tissue after cold acclimation (1984)
    Springer
    The journal of membrane biology 78 (1984), S. 85-89 
    Details
    ISSN: 1432-1424
    Keywords: brown adipose tissue ; gap junction ; cold acclimation ; freeze fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The decrease in the metabolic capacity of rat brown adipose tissue during the late postnatal period can be reversed by cold acclimation of the animals. In order to find out whether a parallel decrease in capability for intercellular communication observed during this period is also reversed by cold acclimation, gap junction size and number per unit area of cell surface have been quantified in freeze-fracture replicas; cell diameters have been measured in semi-thin sections. It was found that the specific number of gap junctions remains unchanged during cold acclimation. However, the mean gap junction size increases by 75% and the ratio of gap junctional area per cell volume, an index for intercellular exchange capacity, is doubled. This result illustrates further the parallelism between metabolic capacity and cell communication in brown fat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01869196
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  • 8
    Electronic Resource
    Electronic Resource
    The response of adipose tissue blood flow to insulin-induced hypoglycemia in conscious dogs and rats (1986)
    Springer
    Pflügers Archiv 406 (1986), S. 37-44 
    Details
    ISSN: 1432-2013
    Keywords: Brown fat ; Adipose tissue ; Dogs ; Rats ; Hypoglycemia ; Catecholamines ; Regional blood flow ; Thermoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A comparative study, focusing on the modification of regional blood flow in adipose tissue during insulin-induced hypoglycemia, was performed on dogs and rats at room temperature (22°C) and on rats at thermoneutrality (28–32°C). Insulin dosages of 3 IU/kg in rats and 0.75 IU/kg in dogs were found to cause changes of comparable amplitude and kinetics in plasma glucose and catecholamine levels in both species. At thermoneutrality, hypoglycemia induced an increase in blood supply to adipose tissue in both species: in dogs, blood flow density was markedly increased from the periphery (+75% in subcutaneous region) to the deeper locations (+550% in perirenal region); in rats, the increase of fractional cardiac output was especially pronounced in brown adipose tissue. By contrast, in rats acclimated at room temperature, hypoglycemia induced a decrease of fractional cardiac output to white adipose tissue and even more markedly, to brown adipose tissue (−45%). These results strongly suggest that, in rats at ambient temperature below thermoneutrality, thermoregulatory heat production is shut off during hypoglycemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582950
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence for a modulating effect of NA+/H+ exchange on the metabolic response of rat brown adipose tissue (1988)
    Springer
    Pflügers Archiv 411 (1988), S. 273-277 
    Details
    ISSN: 1432-2013
    Keywords: Brown adipose tissue ; pH, Na+/H+ exchange ; Amiloride ; α 2-agonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane potential and intracellular pH (pHi) were simultaneously monitored in rat perifused brown adipose tissue fragments by means of double-barrelled microelectrodes. In parallel experiments, the respiratory rate was measured. The cytosolic pH of unstimulated brown adipocytes was about 0.5 units higher than the value expected for a passive transmembrane distribution of H ions. Isoproterenol (5·10−10 M) had no effect on pHi and membrane potential while it induced a 3.1±0.5-fold increase of the respiratory rate. Clonidine (10−7 M) alone was followed by a cytosolic alkalinization of 0.14±0.05 pH units with no concomitant increase in the respiratory rate. A mirror image of the intracellular alkalinization induced by clonidine, i.e. an acidification of 0.09±0.03, was noted by monitoring the extracellular pH. Addition of clonidine in the presence of isoproterenol induced an alkalinization of 0.17±0.03 pH units and a 7.7±1.0-fold increase of the respiratory rate. Thus the alkalinizing effect of clonidine developed despite a massive increase in CO2 production. Pretreatment of the preparation with amiloride (10−3 M), an inhibitor of Na+/H+ exchange, completely prevented the alkalinization and markedly reduced the potentiating effect of clonidine on the isoproterenol-induced respiratory rate. The results obtained are compatible with the hypothesis of a modulating effect of Na+/H+ exchange on the brown adipocyte metabolic response to catecholamine stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585114
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  • 10
    Electronic Resource
    Electronic Resource
    Prepontine knife cut-induced hyperthermia in the rat (1988)
    Springer
    Pflügers Archiv 411 (1988), S. 593-599 
    Details
    ISSN: 1432-2013
    Keywords: Prepontine knife cut ; Brown adipose tissue ; Surgical denervation ; Chemical denervation ; Cardiac output distribution ; Nonshivering thermogenesis ; Hyperthermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of brown adipose tissue (BAT) denervation on the prepontine knife cut-induced hyperthermia was studied. The knife cut has earlier been shown to induced a steady state hyperthermia of 3 to 4°C, as a result of marked activation of the BAT. Before the lesion, the interscapular BAT (IBAT) temperature was lower than the colonic temperature, but the temperature gradient reversed a few minutes after the lesion and the fractional blood flow increased 12-fold. Bilateral sectioning of the 5 nerves supplying IBAT did not modify either the magnitude or the kinetics of the IBAT hyperthermic response. The IBAT fractional blood flow, which was 15 times higher in denervated than in intact tissue before the lesion, scarcely increased following the lesion despite the sharp increase in the tissue's metabolic activity. Chemical sympathectomy with 6-hydroxydopamine suppressed the hyperthermic response. Propranolol or hexamethonium injected i.v. during the steady state hyperthermia resulted in a rapid drop in IBAT temperature and in a reversal of the gradient between IBAT and colonic temperature both in denervated and in intact IBAT. Injection of desipramine, an inhibitor of noradrenaline reuptake, resulted in itself in an increase of temperature in both intact and denervated tissue, which is circumstantial evidence for the presence of a functional residual innervation in the latter. These results indicate that vasomotor fibres run within intercostal nerves supplying IBAT and since severing of these nerves did not prevent the sympathetic stimulation of the tissue, it can be inferred that the residual innervation entering the IBAT along with the blood vessels is conveying stimulating signals originating in peripheral structures. The observation made by Moragas and Toran (1985) of a very active lipolysis in BAT from anencephalic infants are discussed in the context of these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580853
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