ISSN:
1432-1971
Keywords:
Digitoxin intoxication
;
Fab fragments
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A 20-month-old girl with massive digitoxin intoxication (initial digitoxin serum level: 629 ng/ml) was successfully treated with digoxin-specific antibody fragments (Fab). She presented with moderate signs of digitalis toxicity (somnolence, bradycardia, first-degree AV block) and improved rapidly during fractional Fab administration. Free serum-digitoxin disappeared after 6 vials of Fab (480 mg), but was measurable again on days 6 and 7. This case demonstrated that digoxin-specific antibodies, despite a 30–100 times lesser affinity for digitoxin, are effective in massive digitoxin intoxications. A rebound phenomenon may occur several days later and should be taken into consideration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00797008
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