Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effect of exchange transfusion on the elimination of digoxin in neonates (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 25-29 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; exchange transfusion ; pharmacokinetics ; neonates ; 86Rb assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary By means of an86Rb-uptake inhibition assay, changes in the plasma concentration of digoxin and the amount of the glycoside removed during exchange transfusion have been studied in two newborns. For comparison, the exchange procedure was simulated by a computer on the basis of a two-compartment open model and available pharmacokinetic constants. A rapid decrease in plasma digoxin concentration during exchange transfusion was found when the glycoside was administered intravenously or intramuscularly within 60 min before the procedure. The amount of digoxin removed by the exchange was less than 6 per cent of the given dose. Computer simulation of the procedure also showed removal of only a minor amount of digoxin. It is concluded that the decrease in plasma concentration and the removal of only a small amount of glycoside by the exchange transfusion can be attributed mainly to extensive tissue distribution of digoxin. The results imply that replacement of digoxin after an exchange transfusion seems unnecessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561545
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Absorption of digoxin in man after oral and intrasigmoid administration studied by portal vein catheterization (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 39-47 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; portal venous sampling ; absorption rate ; oral administration ; intrasigmoid administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absorption of digoxin has been studied in fasting patients undergoing transumbilical, portal catheterization for diagnostic purposes. A purely aqueous solution was administered orally in 4 patients and in the sigmoid colon in 2 patients. Blood samples were taken simultaneously from the portal and a peripheral vein. Plasma digoxin concentrations were determined by radioimmunoassay. Digoxin appeared early in the blood after oral administration; the average peak of porto-peripheral concentration differences was at 18 min. After intrasigmoid administration, absorption was slower, and no distinct peaks were found. Calculation of the mean amounts absorbed showed that half the dose had been absorbed via the portal vein during 2 hours in the oral study and during 6 hours in the intrasigmoid test. Approximately 2/3 of the dose had been absorbed during 6 hours after oral dosing. The absorption rate was estimated taking into account the decreasing amount of drug left to be absorbed at different times. After oral administration, the mean peak rate was found to correspond to an absorption half-time of 0.78 h, which was more than 20 times faster than the rate after 6 h. The mean peak rate after intrasigmoid administration appeared to be about 1/3 of that after oral dosing. Physiological factors that might account for these differences in absorption rate are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613427
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Bambuterol and terbutaline in human cerebrospinal fluid and plasma (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 147-150 
    Details
    ISSN: 1432-1041
    Keywords: Terbutaline ; Bambuterol ; Cerebrospinal fluid ; plasma ; human ; adverse effects®
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Concentrations in cerebrospinal fluid (CSF) and plasma of bambuterol and its active metabolite, the β2-adrenoceptor agonist terbutaline, were measured in man after four once-daily doses of 30 mg bambuterol hydrochloride (Bambec®). Nine patients scheduled for orthopaedic surgery under spinal anaesthesia completed the study. The concentrations of both substances were much lower in CSF than in plasma, the ratio CSF/plasma being 0.09 for bambuterol and 0.19 for terbutaline, at apparent steady state. While the rank order of the ratios was expected from the fractions of unbound bambuterol and terbutaline in plasma, their absolute values were only about 1/6 (bambuterol) and 1/4 (terbutaline) of those predicted from diffusion equilibria between plasma and CSF. Thus, the rates of transport of bambuterol and terbutaline from plasma into the central nervous system appear to be slow relative to transport out of the system, e.g. by outflow of CSF. The findings are in agreement with animal experiments and suggest that bambuterol and terbutaline are less likely than lipophilic β2-adrenoceptor agonists to interact with central receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315496
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...