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Digitale Medien

Bioinequivalence of marketed diltiazem preparations (1990)

Joshi, M. V. ; Gokhale, P. C. ; Pohujani, S. M. ; [weitere]

Springer

European journal of clinical pharmacology 39 (1990), S. 189-190

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Details

ISSN: 1432-1041

Schlagwort(e): Diltiazem ; bioinequivalence ; plasma concentration ; dissolution ; pharmacokinetics ; commercial brands

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary A bioequivalence study of three brands of regular diltiazem — Angizem (A), Dilzem (B) and Herbesser (C) has been carried out in 5 healthy, male volunteers. After a single oral dose of 60 mg of each preparation, the mean AUC(0–8 h) and Cmax of preparation B was significantly higher than of brands A and C. The tmax of A and B was significantly lower than of C. B had a higher dissolution rate in vitro (98.8% dissolved in 45 min) than A and C. Thus, there was bioinequivalence of the three brands of diltiazem, due partly to differences in dissolution and perhaps in part to a first pass effect.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00280058

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