ISSN:
1432-2013
Keywords:
Diluting segment
;
Furosemide
;
K+-conductance
;
Amiloride
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Experiments were performed in the isolated perfused kidney of K+ adaptedRana pipiens to investigate the relationship between luminal K+ conductance and H+ transport in cells of the diluting segment. Inhibition of luminal Na+/H+ exchange by amiloride or by omission of luminal Na+ blocked luminal K+ conductance. Acidification of the kidney perfusate by elevation of pCO2 also reduced luminal K+ conductance. This effect could be prevented by furosemide. Since the steepest transcellular Na+ potential difference, directed from the lumen into the cell, is found when luminal Na+/Cl−/K+ cotransport is inhibited by furosemide, we conclude that luminal Na+/H+ exchange is most efficient at these conditions and thus could attenuate intracellular acidification.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00581790
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