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  • systolic time intervals  (2)
  • Diphtheritic polyneuropathy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Muskelbioptische Befunde bei der Diphtherie-Polyneuropathie (1981)
    Springer
    Acta neuropathologica 55 (1981), S. 307-318 
    Details
    ISSN: 1432-0533
    Keywords: Diphtheritic polyneuropathy ; Muscle biopsy ; Intramuscular nerves ; Electron microscopy ; Histochemistry ; Diphtherie-Polyneuropathie ; Muskelbiopsie ; intramuskuläre Nerven ; Elektronenmikroskopie ; Histochemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Biopsien aus Extremitätenmuskeln von vier Kranken mit schwerer tetraplegischer Form der Diphtherie-Polyneuropathie konnten nahe dem Höhepunkt der Erkrankung gewonnen und mit modernen Methoden einschließlich Histochemie, Elektronenmikroskopie und morphometrischer Verfahren untersucht werden. Vergleichbare Studien wurden bisher nicht veröffentlicht. Die Muskulatur bot vorwiegend neurogene Veränderungen mit disseminierten angulierten Fasern, eine besonders die Typ-2B-Fasern betreffende, mehr generaliierte Atrophie sowie Targetoidherde oder „Cores” in Typ-1-Fasern. Darüber hinaus fanden sich eindeutige myogene Veränderungen mit unterschiedlichen Degenerationsphänomenen bis zur totalen Nekrose, offenbar — wie am Herzmuskel —toxischer Herkunft. Das neurogen-myogene Mischbild entsprach den elektromyographischen Befunden. Die intramuskulären Gefäße waren unauffällig bis auf vereinzelte perivaskuläre, vorwiegend mononukleäre Zellinfiltrate mit reichlich zerebriformen lymphoiden Zellen, wahrscheinlich T-Lymphozyten. An 11 intramuskulären Nerven und zwei motorischen Endplatten waren eindeutig auf die Diphtherie zu beziehende Veränderungen nicht aufzudecken. Dies kann als Hinweis auf eine vorwiegend proximale Entmarkung bei der Diphtherie-Polyneuropathie des Menschen gedeutet werden, die damit eher der experimentellen Form des Kaninchens als der des Meerschweinchens entspricht.
    Notes: Summary Mucle biopsies from the lower extremities of four patients with severe tetraplegic form of diphtheritic polyneuropathy were examined by modern techniques including histochemistry, electron microscopy and morphometric procedures. Until now comparable studies have not been published. The biopsies were removed during the acute stage of the polyneuropathy. We found scattered small angulated muscle fibers beside a more generalized slight atrophy predominantly of type 2B fibers and targetoid-phenomenons or cores in type 1 fibers. Beside this neurogenic pattern there also were, corresponding with the results of electromyography, primary myogenic alterations with different degenerative phenomenons, suspicious of toxic origin as in cardiac muscle. The intramuscular vessels showed no abnormalities except some perivascular predominantly mononuclear cellular reactions with a remarkable number of cerebriform lymphoid cells, probably T-lymphocytes. No specific pathological alterations could be detected in 11 intramuscular nerves and two motor endplates. This may reflect the more proximal demyelination of human peripheral neurons by the diphtheria toxin as found in experimental diphtheria of the rabbit in contrast to the more distal type of the guinea pig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690995
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cardiocirculatory effects of Ro 11-2464, a selective 5-HT (serotonin) uptake inhibitor, in healthy volunteers (1982)
    Springer
    European journal of clinical pharmacology 21 (1982), S. 357-361 
    Details
    ISSN: 1432-1041
    Keywords: serotonin uptake inhibitor ; tricyclic antidepressants ; systolic time intervals ; Ro 11-2465 ; cardiovascular effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The imipramine derivative Ro 11-2465, a potent, selective 5-HT (serotonin) uptake inhibitor, is being developed as an antidepressant agent. The effects of Ro 11-2465 on heart rate, blood pressure, electrocardiogram and systolic time intervals were assessed in nine normotensive volunteers. Ro 11-2465 1 and 2 mg and a placebo were given in a single blind, cross over design study. The placebo did not induce any significant changes. With Ro 11-2465, the ECG-intervals (P,PQ,QRS,QTc) did not change, the blood pressure increased 3–6 h after administration of either dose, and the heart rate was increased 4–6 h after the 2 mg dose. There was also evidence of increased ventricular automaticity in one subject. The total electromechanical systole (QS2-index) was significantly shortened 4–8 h after administration of 2 mg, whereas neither 1 mg the dose nor the placebo had any such effect. This finding suggests the presence of a positive inotropic effect, which is probably due to a stimulatory effect of serotonin, and is not mediated by an adrenergic mechanism. The findings suggest that Ro 11-2465, as a potential new tricyclic antidepressant, might have favourable cardiocirculatory side effects, particularly in patients with pre-existing heart disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542318
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Cardiocirculatory effects of moclobemide (Ro 11-1163), a new reversible, a short-acting MAO-inhibitor with preferential Type A inhibition, in healthy volunteers and depressive patients (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 173-177 
    Details
    ISSN: 1432-1041
    Keywords: moclobemide (Ro 11-1163) ; MAO-inhibitor ; cardiocirculatory effects ; systolic time intervals ; depressive patients ; control subjects ; chronic treatment ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The benzamide-derivative moclobemide (Ro 11-1163) is a new short-acting, reversible MAO-inhibitor, preferentially affecting Type A MAO, which is, being developed as an antidepressant agent. The effect of moclobemide on heart rate, blood pressure, electrocardiographic and systolic time intervals was assessed in eight healthy volunteers and seven depressive patients. The volunteers received single doses of 100 mg, 150 mg and placebo in radomized single-blind order. Seven patients received placebo and 100 mg as single doses and five patients were also given chronic treatment with individually assessed optimal therapeutic dose (100–400 mg). No change in blood pressure, heart rate, ECG or systolic time intervals was found. The compound was well tolerated. The findings suggest that moclobemide may be a safe MAO-inhibitor as far as sympathetic responsiveness and cardiovascular effects are concerned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543787
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    Paper (German National Licenses)
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