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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 67 (1980), S. 307-310 
    ISSN: 1432-2072
    Keywords: Quipazine ; Antidepressants ; NA ; 5-HT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These three responses are considered to be predictive of an antidepressive action; in these three tests the effects of quipazine are inhibited by d,l-propranolol but not by d-propranolol or methysergide. Quipazine, in mice pretreated with pargyline, induced head twitches which were inhibited by methysergide but not by d,l-propranolol. Quipazine, in addition to its well-known serotonergic effects, seems to have beta-adrenergic properties which should be kept in mind when this drug is used as a pharmacological tool and which suggest that the beta-adrenergic system is implied in depression.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 244 (1994), S. 182-189 
    ISSN: 1433-8491
    Keywords: Recurrent brief depression ; Primary care Suicide ; Severity ; Disability ; Comorbidity ; Recognition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report from the WHO project on Psychological Problems in General Health Care examines the relevance in primary care of the concept of recurrent brief depression (RBD) proposed by Jules Angst. RBD refers to brief, severe depressive episodes that recur frequently, i.e. nearly once a month over, a 1-year period, according to Angst. Using a structured interview (CIDI), RBD was assessed in patients not meeting the criteria for depressive episodes lasting at least 2 weeks, as defined in the ICD-10 (DE). A substantial proportion of primary care seekers were identified as presenting RBD without other depressive disorders, 3.7% with a formal RBD diagnosis and 2.7% with frequent but not monthly depressive episodes. These two subgroups were found to differ very little in terms of sociodemographic characteristics, severity, disability, and comorbidity with other diagnoses. However, in patients with a formal diagnosis of RBD, a higher rate of history of suicide attempts was found (14.0%), similar to that observed in patients meeting the criteria for DE. Most of the severity and disability indicators show that RBD is a severe condition, associated with substantial impairment, even if they show a higher degree of severity for DE. About one RBD patient out of three is recognized by general practitioners as presenting a psychological disorder, a majority of whom are atually treated. Our results confirm the relevance of the concept of RBD in primary care, and the need to further, explore the pertinence of the restrictive recurrence criterion proposed by Angst.
    Type of Medium: Electronic Resource
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