ISSN:
1432-2072
Keywords:
d-Amphetamine
;
CNS Stimulants
;
Discrimination
;
State-Dependent Learning
;
Hallucinogenic Drugs
;
δ 9-THC
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Male albino rats were trained and tested on a two-lever discrimination task based upon the presence or absence of d-amphetamine (1.0 mg/kg). This compound was found to produce strong discriminative cues (i.e., 90% correct choice behavior). A dose-effect function was then ascertained and the discriminative ED50 (following training with 1.0 mg/kg) was found to be 0.23 mg/kg d-amphetamine. In order to determine the effective duration of d-amphetamine action, the interval between injection and testing was varied; it was found that the discriminative effects of the drug began to dissipate between 60 and 90 min post-injection. In an attempt to compare the discriminative cues of other drugs with those of d-amphetamine, injections of LSD (0.04 and 0.08 mg/kg), psilocybin (0.50 and 1.0 mg/kg), THC (0.50 and 1.0 mg/kg), mescaline (5.0 and 10.0 mg/kg), and caffeine (6.0 and 20.0 mg/kg) were given during extinction. In all cases, the rats responded predominantly on the saline-related lever. Only methamphetamine (1.0 mg/kg) produced d-amphetamine-like responding. Finally, alpha-methyl-para-tyrosine (AMPT), a compound which depletes brain catecholamines (CA), was found to disrupt the d-amphetamine-saline discrimination.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421458
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