Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Absorption of14C-methylscopolamine from the digestive tract (1971)
    Springer
    European journal of clinical pharmacology 4 (1971), S. 46-51 
    Details
    ISSN: 1432-1041
    Keywords: anticholinergics ; gastrointestinal agents ; intestinal absorption ; parasympatholytics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary 14C-methylscopolamine (1.5 or 15 mg) and the non-absorbable markers polyethylene glycol or125I-polyvinyl pyrolidon were taken by mouth or infused directly into the duodenum or the upper jejunum of 8 healthy subjects. Comparison of the radioactivity per unit quantity of marker in intestinal aspirates and in the test solution (A/T ratio) showed that about 20 per cent or less of the label was absorbed during its passage through the upper part of the small intestine. Very small amounts of14C-radioactivity were found in the plasma. Over a 7-day period the urinary excretion of label amounted to 7–15 per cent of the dose given. The A/T ratios and urinary excretion of14C-radioactivity showed that there was no consistent relation between the absorption of14C-label and the dose of methylscopolamine administered or the type of non-absorbable marker used. There was no evidence of breakdown of the drug in the upper small intestine. — In a 9th subject, labelled methylscopolamine was instilled into the middle part of the jejunum. The yield of14C-radioactivity in the urine was only 2.6 per cent, which indicates very poor absorption of the drug from the distal jejunum, ileum or colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00568898
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Uptake in the human small intestine of a quaternary anticholinergic compound (Acabel) (1971)
    Springer
    European journal of clinical pharmacology 3 (1971), S. 93-96 
    Details
    ISSN: 1432-1041
    Keywords: Anticholinergics ; gastrointestinal agents ; intestinal absorption ; parasympatholytics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The anticholinergic compound Acabel (the benzilic acid ester of N,N-dimethyl-2-hydroxy-methyl-piperidinium-methyl sulphate), tritium labelled in the piperidine molecule, was administered to 6 healthy voltunteers. Its absorption was measured by comparing the radioactivity in gastrointestinal aspirates with that of an unabsorbed marker. The main uptake of Acabel was localized in the upper part of the small intestine, and amounted to 10–20% of the given dose. — Studiesin vitro showed that3H-Acabel can be metabolized in the small intestine. However,in vivo there was no evidence of its decomposition while the test solution was passing through the proximal part of the digestive tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619300
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 385-387 
    Details
    ISSN: 1432-1041
    Keywords: Diuretic ; drug interaction ; gastrointestinal absorption ; hydrochlorothiazide ; propantheline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Hydrochlorothiazide 75 mg was given twice p.o. to fasting subjects. In the second study they had been pretreated with propantheline 60 mg. Plasma and urine concentrations of hydrochlorothiazide were determined by GLC. Pretreatment with propantheline on average delayed the maximal plasma level of hct from 2.4 to 4.8 h (p〈0.05); and the total urinary recovery of hydrochlorothiazide by 48 h was increased from 49.3 mg to 66.9 mg (p〈0.005). It was concluded that propantheline increased substantially the absorption of the diuretic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644613
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Gastrointestinal absorption of certain anticholinergic drugs (1972)
    Springer
    European journal of clinical pharmacology 5 (1972), S. 87-92 
    Details
    ISSN: 1432-1041
    Keywords: Anticholinergics ; gastrointestinal agents ; intestinal absorption ; parasympatholytics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A radiochemical technique has been employed to study gastrointestinal absorption of anticholinergic drugs in healthy human subjects. The uptake of all the drugs was largely confined to the most proximal part of the small intestine. Absorption of the tertiary amine atropine was almost 100 per cent and was significantly greater than that of the quaternary nitrogen compounds studied. Of the latter, 15–25 per cent of methylatropine, Acabel® and methylscopolamine were absorbed; very little butylscopolamine was taken up. Hydrolysis of propantheline in the upper small intestine prevented determination of the absorption of the intact drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561751
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...