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  • 1
    Electronic Resource
    Electronic Resource
    Morphine abstinence and serotonin supersensitivity in man: Analogies with the mechanism of migraine? (1979)
    Springer
    Psychopharmacology 65 (1979), S. 205-209 
    Details
    ISSN: 1432-2072
    Keywords: Serotonin ; Dopamine ; Central peripheral supersensitivity ; Mild morphine abstinence ; Nonorganic central pain ; Migraine attack ; Computerized venotest
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mild (10–24 mg/day) and limited (3 days) treatment. To evaluate the sensitivity to serotonin, dopamine, noradrenaline, and tyramine in the smooth muscle of the hand dorsal vein, in vivo, the computerized venotest was applied before, during, and 24 h after withdrawal of morphine. Venous sensitivity to serotonin and dopamine (but not to noradrenaline and tyramine) increased 10- to 20-fold after morphine withdrawal. Venous monoamine supersensitivity in morphine abstinence, similar to that observed during migraine attacks, could be indirect evidence of an analogous mechanism in both conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433050
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    5-Hydroxytryptamine supersensitivity as a new theory of headache and central pain: A clinical pharmacological approach with p-chlorophenylalanine (1973)
    Springer
    Psychopharmacology 29 (1973), S. 347-356 
    Details
    ISSN: 1432-2072
    Keywords: 5-Hydroxytryptamine ; p-Chlorophenylalanine ; Central Pain ; Supersensitivity ; Essential Headache
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vascular supersensitivity to 5-hydroxytryptamine, but not to noradrenaline is observed in volunteers suffering from untreatable migraine, following treatment with parachlorophenylalanine, a specific serotonin depletor. A similar supersensitivity at brain level is claimed to explain an unusual systemic pain syndrome developed in 4 patients affected by migraine and treated with this serotonin depleting agent; hyperalgesia, hyperpathia, spontaneous pain, according to the picture of central pain, are demonstrable. The pain syndrome is reversible with the drug discontinuation; it reappears promptly when the treatment is started again. The pain from serotonin depletion may represent a chemical approach to the mechanism of central pain, such as thalamic syndrome, and may give a new suggestive light to the serotonin interpretation of migraine and some daily headaches. The increased vascular and nervous responsitivity in patients suffering from migraine, to monoamines and correlated drugs (5-HT, noradrenaline, metaraminol, LSD-25 and psylocibine), may be interpreted in terms of central and peripheral monoamine supersensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429282
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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