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  • Dopamine antagonists  (1)
  • dihydroxyanthracenedione  (1)
  • mitoxantone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Corticosteroids, dopamine antagonists and other drugs (1998)
    Springer
    Supportive care in cancer 6 (1998), S. 204-214 
    Details
    ISSN: 1433-7339
    Keywords: Key words Corticosteroids ; Dopamine antagonists ; Canabinoids ; Benzodiazepines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The literature on corticosteroids, dopamine antagonists and other antiemetics, such as cannabinoids and benzodiazepines, was reviewed and presented at a consensus conference on antiemetics. Based on the reviews and the discussion during the conference, guidelines for the use of these agents are given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050155
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Prospective study of left ventricular function using radionuclide scans in patients receiving mitoxantrone (1983)
    Springer
    Investigational new drugs 1 (1983), S. 341-347 
    Details
    ISSN: 1573-0646
    Keywords: mitoxantrone ; dihydroxyanthracenedione ; anticancer drug ; cardiotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A prospective Phase II study to evaluate the effects of mitoxantrone on left ventricular ejection fraction (LVEF) has been carried out in patients treated with 12 mg/m2 every three weeks. Gated radionuclide cardiac blood pool imaging with assessment of LVEF and wall motion prior to and during graded exercise was performed before the first and every other mitoxantrone course. Ten patients had either a minor response or tumour stabilization while receiving mitoxantrone treatment and underwent serial radionuclide scans during the course of therapy. Three patients who had received adriamycin as part of prior chemotherapy regimens showed no evidence of cardiotoxicity. Seven patients, who had had no prior adriamycin exposure, underwent serial radionuclide studies while receiving up to 204 mg/m2 of mitoxantrone. None of these patients showed evidence of clinically significant myocardial damage. One had a decline in LVEF from 70% to 50% at a maximum dose of 108 mg/m2. An additional patient whose LVEF rose from 57% at baseline to 62% at a total dose of 204 mg/m2 (17 courses) underwent endomyocardial biopsy which showed grade 2.5 anthracyclinetype cardiotoxicity. Serial endomyocardial biopsy studies are indicated in patients on longterm drug therapy to determine the incidence, dose-relationship and severity of potential mitoxantrone associated endomyocardial damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177420
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Phase II trial of mitoxantrone in head and neck cancer (1984)
    Springer
    Investigational new drugs 2 (1984), S. 329-330 
    Details
    ISSN: 1573-0646
    Keywords: mitoxantone ; head and neck cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Mitoxantrone (1,4-dihydroxy-5,8-bis((2-[(2-hydroxyethyl)amino]ethyl)amino)-9, 10 anthracenedione dihydrochloride, NSC 301,739) is a new aminoanthraquinone derivative with clinical activity in the treatment of advanced breast cancer (1, 2), lymphoma (3), and acute leukemia (4). We have carried out a phase II trial of mitoxantrone using an every three weeks dosing schedule in patients with advanced head and neck cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175386
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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