ISSN:
1432-2072
Keywords:
Dorsal raphe nucleus
;
Rat
;
WAY-100635
;
8-OH-DPAT
;
Somatodendritic 5-HT1A receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT1A receptor antagonist WAY-100635 [N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclo-hexanecarboxamide trihydrochloride]. This blockade was demonstrated both after systemic and DRN application of WAY-100635. Therefore, it is concluded that the anxiolytic effects of 8-OH-DPAT are mediated by activation of somatodendritic 5-HT1A receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02247397
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