ISSN:
1432-1041
Keywords:
Dose-response relationship
;
tolbutamide
;
glibenclamide
;
diabetes mellitus
;
intravenous glucose test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Using a new procedure to study the dose-response relationships of sulphonylureas, the effects of tolbutamide and glibenclamide on blood sugar and serum insulin have been examined in 9 diabetic patients. Particular changes sought in serum insulin were alteration in the two initial peaks, elevation of basal levels and augmentation of the response to glucose infusions. In general, both sulphonylureas had identical effects and glibenclamide was not superior to tolbutamide. In 3 or 4 obese patients the first of the two initial insulin peaks was as high as in healthy volunteers, whereas the second peak was diminished; both initial peaks were greatly reduced in non-obses patients. The basal level of insulin was elevated in only one patient after glibenclamide. The response of insulin levels to glucose infusions was not increased in any patient and was actually inhibited by glibenclamide in one case. Tolbutamide produced its maximal effects after a dose of 1.0 g, glibenclamide after 1 mg. Blood sugar levels declined more rapidly in patients with latent diabetes than in those with the overt disease. In two of the latter, the fall in blood sugar was not associated with a corresponding increase in serum insulin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558200
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