ISSN:
0570-0833
Schlagwort(e):
Double asymmetric synthesis
;
Asymmetric synthesis
;
Stereochemical control
;
Aldol reaction
;
Diels-Alder reaction
;
Hydrogenation
;
Epoxidation
;
Chemistry
;
General Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
This account examines double asymmetric induction from theoretical and practical viewpoints. In the context of four major organic reactions-the aldol, Diels-Alder, catalytic hydrogenation, and epoxidation-it is shown that a double asymmetric induction can be analyzed in terms of the single asymmetric reactions of each of the two chiral reactants. A rule which qualitatively relates the results of these single asymmetric reactions with the outcome of the double asymmetric reaction is proposed. A powerful new strategy based on this rule for the predictable creation of new chiral centers is discussed and the use of this strategy for the synthesis of sugars and macrolides is presented.
Zusätzliches Material:
7 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/anie.198500013
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