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  • 1
    Electronic Resource
    Electronic Resource
    Age-related changes of whole skeleton and body composition in healthy men (1995)
    Springer
    Calcified tissue international 57 (1995), S. 336-339 
    Details
    ISSN: 1432-0827
    Keywords: Total body absorptiometry ; Bone mineral density ; Lean mass ; Fat mass ; Healthy males
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract We examined age-related changes of the entire skeleton and its major anatomical areas (spine, trunk, pelvis, arms, legs) in 139 healthy males (19–99 years of age) and evaluated the influence of lean mass and fat mass on these changes. The population studied was stratified according to their ages referred in decades. Bone mineral density (BMD) and body composition (fat mass, lean mass) were measured by Lunar DPX. A negative linear correlation between BMD values and age was observed. The overall bone loss from the young to the aged was statistically significant for all skeletal sites, with a lower level of significance for the spinal area: BMD percentage decrease ranged from 19.4% for the pelvis to 9% for the spine. Peak bone mass was observed in the first decade (19–29 years of age). Soft tissue increased until the fifth and sixth decades, followed by a gradual decrease. Lean mass declined in a uniform way from the first to the last decades. BMD values were significantly related to lean mass, but there were no correlations with the fat mass. Lean body mass was significantly related to BMD/height, index of “true” volumetric density. Multiple regression analysis confirmed that in males the principal determinant of total body bone density is fat-free mass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302068
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  • 2
    Electronic Resource
    Electronic Resource
    The variable incidence of hip fracture in Southern Europe: The MEDOS study (1994)
    Springer
    Osteoporosis international 4 (1994), S. 253-263 
    Details
    ISSN: 1433-2965
    Keywords: Doubling time ; Excess female morbidity ; Gonadal function ; Hip fracture ; Incidence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We assessed the incidence of hip fracture and ecological correlates in residents of 14 communities in six countries of Southern Europe. Hip fracture cases were recorded prospectively in defined catchment areas over a 1-year interval. A retrospective questionnaire was used to assess ecological differences between communities. During a 1-year period of observation a total of 3629 men and women over the age of 50 years were identified with hip fracture from a catchment of 3 million. In all communities the fracture rate increased exponentially with age. There were large and significant differences between centres in the doubling time for hip fracture risk with age and in crude and age-standardized rates. Greater than 4-fold and 13-fold differences in age-standardized risk were found amongst men and women respectively. The lowest rates were observed from Turkey and the highest from Seville, Crete and Porto. Fractures were significantly more frequent among women than men with the exception of three rural Turkish centres. Indeed, in rural Turkey the normal female/male ratio was reserved. Variations in incidence between regions were greater than the differences within centres between sexes, and there was a close and significant correlation between incidence rates for men and those for women in the regions studied. Excess female morbidity increased progressively from the age of 50 years but attained a plateau after the age of 80 years, suggesting a finite duration of the effect of the menopause. The retrospective questionnaire completed by 80% of cases suggested that differences in incidence between the communities studied could not be explained by differences in gonadal status in women. In both men and women cross-cultural associations were found with factors related to age or socioeconomic prosperity, the majority of which disappeared after adjustment for age. We conclude that there are marked and sizeable differences in the incidence rates of hip fracture throughout Southern Europe. The reasons for these differences are not known but affect both men and women, and are likely to be related to lifestyle or genetic factors rather than to differences in endocrine status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623349
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    Paper (German National Licenses)
    Fulltext
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