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  • 1
    Electronic Resource
    Electronic Resource
    Therapeutic effectiveness of segmental arterioportal chemoembolization via hepatic artery for localized hepatocellular carcinoma (1992)
    Springer
    European radiology 2 (1992), S. 413-420 
    Details
    ISSN: 1432-1084
    Keywords: Hepatocellular carcinoma ; Iodized oil ; Doxorubicin ; Arterial chemotherapeutic embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Segmental arterioportal chemoembolization via hepatic artery with overflow to the segmental portal vein was performed in 41 patients with hepatocellular carcinoma. Emulsion of doxorubicin (mean 37 mg) and two-to-three volume of iodized oil (mean 11 ml) was infused from a segmental artery of the liver until the segmental portal branches around the tumor were visualized fluoroscopically. By the iodized oil accumulation, the tumors were divided into five types: single nodular (SN); single nodular with proliferation (SN-P); multinodular fused (MN-F); multinodular (MN); and massive. Massive and MN types showed high incidence of local recurrence. However, SN-P and MN-F types showed a good tumor response and no local recurrence. In 32 unresected cases the overall response rate was 53%, the 1-year actuarial survival was 90% and 3-year survival was 43%. Six of nine operative specimens revealed complete necrosis of the tumor microscopically and three showed 90–95% necrosis. Thick fibrous capsules were found in all nine resected cases around the necrosis both of the tumor and of the non-cancerous parenchyma. This therapy was regarded as having a great capacity to kill the infiltrative portion of localized tumor and the thick capsule may be a peculiarity of this therapy which played a major role in guarding against regrowth of the tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176346
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Augmentation of mixed lymphocyte response stimulatory activity by phorbol ester (1984)
    Springer
    Journal of clinical immunology 4 (1984), S. 228-234 
    Details
    ISSN: 1573-2592
    Keywords: Phorbol ester ; mixed lymphocyte reaction ; leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a variety of phenotypic changes on normal and malignant cells. In chronic and acute lymphocytic leukemia we have observed a marked augmentation in mixed lymphocyte reaction stimulatory capacity (MLRs) following pretreatment of leukemia blasts with TPA. We have now characterized the effects of TPA on MLRs utilizing the non-T, non-B lymphoblastic leukemiacell line, HOON. Following pretreatment with TPA (optimal concentration, 1.6×10−10 M), but not with other phorbol esters, there was a marked increase in MLRs, particularly at lower stimulator-cell concentrations. This effect was maximal following a 44-hr preincubation period and the enhancement in MLRs was not accompanied by changes in levels of Ia expression. This cell line provides a model for determining the molecular basis for the TPA-induced augmentation of stimulatory capacity in the mixed lymphocyte reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00914970
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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