ISSN:
1432-0738
Keywords:
Aristolochic acid
;
Adriamycin
;
Drosophila
;
Mutagenicity
;
Recombinogenicity
;
Genotoxicity tests
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Aristolochic acid (AA) has been tested for genotoxic activity in three different assays with Drosophila melanogaster (i–iii). AA induced sex-linked recessive lethals (i) and chromosome losses (ii) in male germ cells. In a newly developed fast assay with somatic cells of larvae (iii), AA induced mutant single spots as well as twin spots. The data indicate that in addition to the mutagenic activity, AA also possesses recombinogenic activity leading to somatic recombination in mitotically active cells. The experimental labor involved to detect the genotoxic activity of AA was lowest with the somatic cell assay.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00333420
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