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  • 1
    Electronic Resource
    Electronic Resource
    Identification of endotoxin-positive cells in the rat lung during shock (1984)
    Springer
    Virchows Archiv 404 (1984), S. 197-211 
    Details
    ISSN: 1432-2307
    Keywords: Endotoxin shock ; Lung ; Endotoxin-positive cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following an intravenous administration into rats of a shock-inducing dose of endotoxin (2 mg) the lipopolysaccharide (LPS) was demonstrated immunohistochemically (light and electron microscopy) and determined quantitatively (radio-labelled LPS) in the lung tissue and in isolated alveolar macrophages. At different times after LPS injection morphological investigations of the pulmonary tissue and alveolar macrophages were carried out. One hour after endotoxin treatment 3% of the alveolar macrophages were already LPS-positive. The maximum extent of the immunoperoxidase reaction for endotoxin (100% cells involved) was observed on day 3, the vast majority (98%) of the alveolar macrophages being LPS-positive still on day 14. 0.9% of the injected radio-labelled LPS preparation was found to be associated with lung tissue on day 3. By this time 0.173 µg LPS/106 alveolar macrophages was detected. During the time of ultrastructural investigation endotoxin appeared in the lung only within cells. By their high capacity for storing endotoxin and their numerical superiority the mononuclear phagocytes are the leading LPS-positive cells in the lung, although granulocytes, endothelial cells, and alveolar epithelial cells were sometimes also involved. The accumulation of a high percentage of activated macrophages in the lung seen in the late stage of shock could represent at least one of the main factors leading to damage of pulmonary tissue. The correlation between appearance of LPS-positive macrophages and histological signs of lung tissue injury in the present investigation is striking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00704064
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chromosomal and behavioral studies of MexicanDrosophila. I. Vagility characteristics of three populations ofD. pseudoobscura (1983)
    Springer
    Behavior genetics 13 (1983), S. 197-204 
    Details
    ISSN: 1573-3297
    Keywords: Drosophila pseudoobscura ; vagility ; Sakai system ; inversion polymorphism ; genotypic variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract Twelve isofemale lines from each of three MexicanDrosophila pseudoobscura populations, known to differ in their degrees of inversion polymorphism, were tested for vagility in the Sakai system. It was found that the flies from the most chromosomally polymorphic population (Zirahuen) had both a significantly lower vagility score and a higher level of expressed genotypic variation for vagility than the flies from the lesser chromosomally polymorphic populations (Amecameca and Tulancingo). The latter two populations could not be distinguished for either parameter of this behavioral trait. The possible role of inversion polymorphism, especially as related to the number of heterozygote combinations formed, in affecting vagility is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01065668
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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