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  • 1
    Electronic Resource
    Electronic Resource
    Inflammatory bowel disease and the genes for the natural resistance-associated macrophage protein-1 and the interferon-Á receptor 1 (1999)
    Springer
    International journal of colorectal disease 14 (1999), S. 13-17 
    Details
    ISSN: 1432-1262
    Keywords: Key words Crohn's disease ; Inflammatory bowel disease ; Interferon-γ receptor1 ; Natural resistance associated macrophage protein-1 ; Polymorphisms ; Ulcerative colitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The genes for the interferon-γ receptor1 and the natural resistance-associated macrophage protein1 (NRAMP1) control the immune response to intracellular microbial pathogens. Such pathogens, in particular Mycobacterium paratuberculosis, have been implicated in the pathogenesis of Crohn's disease. We studied markers in the genes for NRAMP1 and two mutations in the interferon-γ receptor in relation to inflammatory bowel disease (IBD) in the following groups: 270 healthy individuals, 74 patients with Crohn's disease, 72 patients with ulcerative colitis, and 40 patients with primary sclerosing cholangitis. We studied the allele frequencies of two restriction fragment length polymorphisms in the gene for NRAMP1 and the prevalence of two mutations in the interferon-γ receptor1 gene. The markers in the NRAMP1 gene were not associated with inflammatory bowel disease. Also, the mutations in the interferon-γ receptor1 were not found in the 186 IBD patients. Genetic markers in NRAMP1 are thus not associated with IBD. Therefore this gene is not likely to play a role in the pathogenesis of IBD. The mutation in the interferon-γ receptor was not found in our IBD patients group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050177
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  • 2
    Electronic Resource
    Electronic Resource
    Formulation and stability of a beclomethasone dipropionate enema (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 20-22 
    Details
    ISSN: 1573-739X
    Keywords: Beclomethasone ; Chromatography, high pressure liquid ; Chromatography, thin layer ; Drug compounding ; Drug stability ; Enema ; Mesalazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A beclomethasone dipropionate (BDP) enema and a BDP/mesalazine combination enema (containing 2 mg BDP and 1 g mesalazine and 2 mg BDP, respectively per 40 ml) were formulated. BDP and mesalazine were suspended in a carbomer-water gel. No degradation of BDP was measured during the storage period of the BDP enema (4 weeks at 20°C) and of the BDP/mesalazine enema (44 days at 4°C, 20°C and 37°C, respectively). Progressive darkening of colour occurred for the BDP/mesalazine enema during storage at 20°C and at 37°C, probably induced by mesalazine degradation products. Only very slight colouring was observed at 4°C. Hardly any precipitation of BDP and mesalazine was seen during the storage period and the enemas could easily be resuspended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972910
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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