ISSN:
1432-2072
Keywords:
Phentermine self-administration
;
Drug dependence
;
Anorectics
;
Food deprivation
;
Rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In the present experiment graded doses of phentermine, an anorectic similar to amphetamine in structure and mechanism of action, were made available to naive free-feeding (FF) or 80% free-feeding weight (FFW) rats for IV self-administration. Findings showed that, in 80% FFW rats, the number of injections taken were an inverted U-shaped function of dose, whereas the amount of drug injected was a monotonically increasing function of dose. FF animals, however, failed to self-administer phentermine at rates that differed significantly from FF animals self-administering saline. These data suggest that the clinical use of anorectics which have a mechanism of action similar to amphetamine may increase the risk of drug dependence whenever weight loss is achieved.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00429655
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