ISSN:
1432-2072
Keywords:
Writhing
;
Δ 9-Tetrahydrocannabinol
;
Cannabidiol
;
Abdominal constriction
;
Drug interactions
;
Cannabinol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The ability of Δ 9-tetrahydrocannabinol (THC), cannabinol (CBN), cannabidiol (CBD), 11-OH THC and 8α,11-diOH THC to antagonise the abdominal constriction response in the mouse induced by formic acid, phenylquinone, 5-hydroxytryptamine, prostaglandin E1 (PGE1) and bradykinin was tested. THC was an effective antagonist against all nociceptive agents with an ED50 in all cases between 1.0 and 2.6 mg/kg. CBN, while also effective against all nociceptive agents, was less potent than THC, with an ED50 range between 46.2 and 112.5 mg/kg. CBD in doses as high as 200 mg/kg was without effect. Using PGE1 as the nociceptive agent, 11-OH THC was equipotent to THC while 8α,11-diOH THC was inactive. Naloxone, while able to antagonise the antinociceptive effect of morphine against formic acid-induced writhing, did not reverse the antinociceptive effects of THC. There were no pharmacological interactions between THC, CBD and CBN.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432273
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