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  • Drug stability  (1)
  • Protein biosynthesis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures (1994)
    Springer
    Journal of cancer research and clinical oncology 120 (1994), S. 359-364 
    Details
    ISSN: 1432-1335
    Keywords: Estrogen receptor ; Estrogenic plantinum(II) complex ; Luciferase ; Transfection ; Drug stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A rapid assay system for measuring the potential of estrogenic drugs is introduced. Luciferase induction could be measured in estrogen-receptor-positive human MCF-7 breast cancer cells, which had been transfected with a novel luciferase reporter plasmid ERE luc. The minimal requirement was 1 h exposure to the inducing drug and 3.5 h of incubation after removal of the drug. The assay system was used to measure the stability of the drug diaqua-[1,2-bis (2,6-dichloro-4-hydroxyphenyl) ethylenediamine] platinum(II) sulfate, containing an estrogenic ligand and reactive platinum. Luciferase activity was observed only when the drug was in the culture medium and cells for short times, whereas the estrogenic ligand alone remained active. It is assumed that binding of the platinum moiety to macromolecular constituents of the culture or cells renders the drug inaccessible for binding to the estrogen receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01247461
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  • 2
    Electronic Resource
    Electronic Resource
    Protein Biosynthesis: The Codon-Specific Activation of Amino AcidsDedicated to Professor Hermann Hartmann (1978)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 17 (1978), S. 648-656 
    Details
    ISSN: 0570-0833
    Keywords: Protein biosynthesis ; Amino acids ; RNA ; tRNA ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: At the start of protein biosynthesis the amino acids are chemically activated by esterification with transfer ribonucleic acids bearing the appropriate anticodons. The esterification is catalyzed with an exceptionally high specificity by aminoacyl-tRNA synthetases. Current knowledge of the structural properties of the reactants, the course of the reaction, and the reasons for its specificity are summarized.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.197806481
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    Paper (German National Licenses)
    Fulltext
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