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  • 1
    Electronic Resource
    Electronic Resource
    The effects of chronic alcohol ingestion and alcoholic liver disease on binding of drugs to serum proteins (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 435-438 
    Details
    ISSN: 1432-1041
    Keywords: Drug-protein binding ; liver disease ; alcohol ; bilirubin ; albumin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding of salicylate, sulphadiazine and phenylbutazone in whole serum of patients with alcohol-induced liver disease has been compared to that of chronic alcoholics with no evidence of liver disease, and normal healthy subjects. Binding of all three drugs was normal in the chronic alcoholic group, but decreased in patients with alcoholic liver disease. In subjects with alcoholic hepatitis, this decrease appeared to be correlated with variations in serum bilirubin and albumin levels. These observations may be of clinical relevance to the distribution of drugs in alcoholic patients with accompanying hepatic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566322
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Decreased drug binding in serum from patients with chronic hepatic disease (1976)
    Springer
    European journal of clinical pharmacology 9 (1976), S. 429-432 
    Details
    ISSN: 1432-1041
    Keywords: Drug-protein binding ; hepatic disease ; salicylate ; sulphadiazine ; phenylbutazone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The binding of 3 drugs to serum proteins of patients with chronic hepatic disease has been studied by an ultrafiltration technique, and compared to that of normal subjects. The binding of phenylbutazone was reduced in all patients, salicylate in patients with inactive liver disease and sulphadiazine in patients whose disease was active. Analysis of binding data showed a real reduction in the capacity of albumin to bind the drugs in the majority of patients. Addition of bilirubin to normal plasma caused a reduction in sulphadiazine binding, but had no effect on the binding of salicylate or phenylbutazone. The possible causes of this reduction in binding are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606560
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Sedation in intensive care: morphine and renal function (1986)
    Springer
    Intensive care medicine 12 (1986), S. 359-365 
    Details
    ISSN: 1432-1238
    Keywords: Sedation ; Morphine ; Renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intravenous morphine infusions have been administered to 12 critically-ill patients during controlled ventilation. Acute oliguric renal failure was present in 4 patients, who were treated with a combination of haemofiltration and haemodialysis. Severity of physiological disturbance was assessed using a modified APACHE Score, level of sedation by a linear-analogue scale, and blood morphine levels by high-pressure liquid chromatography. Morphine clearance was impaired in renal failure, and was dependent on haemofiltration volumes; accumulation of morphine did not occur during this form of treatment. Conscious level was clearly more closely related to the degree of physiological disturbance than blood morphine levels; and for a given blood morphine level, depression of consciousness was more pronounced the greater the degree of physiological disturbance. Use of a physiological sickness score may help to clarify some of the factors influencing cerebral function during critical illness. Careful clinical monitoring of level of sedation is important in patients with oliguric renal failure receiving morphine, and haemofiltration appears to reduce the risk of morphine accumulation in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292926
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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