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  • fluphenazine  (2)
  • Dynamic exercise  (1)
  • 1
    ISSN: 1435-1463
    Keywords: Catalepsy ; fluphenazine ; sulpiride ; striatum ; phencyclidine ; Parkinson's disease ; MK801 ; CPP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subcutaneous administration of fluphenazine elicits catelepsy that can be attenuated by the glutamate antagonists MK801 and phencyclidine (PCP). 3-[-(+)-2-carboxy piperazine-4-yl]-propyl-1-phosphanate (CPP) was found to be ineffective in this model. Intrastriatal injections of sulpiride or fluphenazine were also found to induce catalepsy which could be attenuated by MK801 and PCP. These results illustrate that nondopaminergic compounds might possibly be of value in the treatment of Parkinson's disease. Furthermore it was demonstrated that this paradigm can be utilized to investigate neurotransmitter interactions within the striatum. This was clearly emphasized by the observation that bilateral administration of MK801 into the striatum increased basal locomotor activity.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1463
    Keywords: Catalepsy ; fluphenazine ; sulpiride ; striatum ; quinpirole ; Parkinson's disease ; L-DOPA ; amphetamine ; apomorphine ; SKF 38393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Catalepsy was observed in the rat following intrastriatal injections of the dopamine antagonists sulpiride or fluphenazine and after subcutaneous administration of fluphenazine. The neuroleptic-induced catalepsy was reversed by the classical anti-parkinsonian agent L-DOPA and by agents that function through dopamine systems such as d- and methamphetamine and the direct D2 receptor agonist quinpirole. The D1 agonist SKF 38393, and the D1/D2 agonist apomorphine, were ineffective in this model. These results support limited use of the rat catalepsy model for the screening of potential anti-parkinsonian compounds and indicate that this procedure can provide valuable information concerning striatal dopamine function.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 58 (1988), S. 152-157 
    ISSN: 1439-6327
    Keywords: Static exercise ; Dynamic exercise ; Heart rate ; Blood pressure ; Systolic time intervals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cardiovascular response to static exercise has often been quantified on the basis of a comparison between static handgrip and dynamic cycling exercise. It is then difficult to make precise comparisons because the physical units of work are not compatible. If the data from dynamic exercise can be used to predict the cardiovascular response to zero movement (static exercise) this would suggest that static exercise is not fundamentally different from dynamic exercise. Using leg extension exercise which lasted for 1 min, a set of weights was lifted repeatedly 50 times/min, through three different distances. On each occasion, the heart rate, systolic time intervals (STI) and systemic arterial blood pressure were monitored non-invasively. Regression analysis of heart rate (HR) or blood pressure (BP) against the distance moved by the weights was used to predict the heart rate or blood pressure that would be expected for static exercise. In addition the same responses were measured following 1 min of static exercise during which the weights were held up but not moved. Five subjects, trained in leg extension exercise, completed the four exercise sessions in a random order. A constant force was produced in each variant of the protocol and in the static exercise it amounted to 50% maximal voluntary contraction (MVC). The forces developed and the distance the weights were lifted were monitored. During this sustained static exercise at relatively low intensity the cardiovascular changes could be predicted from the responses induced by dynamic exercise. It is suggested that other factors are important in determining the cardiovascular response to exercise, not simply the mode.
    Type of Medium: Electronic Resource
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