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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 17 (1989), S. 361-366 
    ISSN: 1434-0879
    Keywords: Immunisation ; Protection against urinary infection ; Urine antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunisation of mice with SolcoUrovac® vaccine induced an approximately 10-fold increase of the total amount of IgG and a 2-fold increase of IgA immunoglobulins in urine. IgG antibodies to Solco-Urovac antigens appeared in urine after the first injection, and booster injections caused a further increase of the titer. IgA antibodies appeared in the urine after the second injection, and the third injection doubled the titer. IgM immunoglobulins and specific IgM class antibodies to Solco Urovac were not found in any urine tested. The exact origin of the immunoglobulins in the urine as well as the spcificity of immune response is discussed.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 20 (1992), S. 177-181 
    ISSN: 1434-0879
    Keywords: Immunization ; Experimental pyelonephritis ; Protection against UTI ; E. coli ; Klebsiella ; Proteus vaccine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The protective effect of immunization with a polyvalent vaccine (SolcoUrovac) was studied in the mouse and the rat. The i.m. immunization increased the resistance of mice to challenge infection with all homologous strains of bacteria. The LD50 values for E. coli, Proteus mirabilis and Streptococcus were 3.5–4.5 times and that of Klebsiella as much as 600 times that in nonimmunized mice. Protection against challenge with heterologous E. coli was also achieved and persisted for about 20 weeks. Immunization with the vaccine also provided marked protection against pyelonephritis in rats. Kidneys with abscesses were seen only one-third as often as in controls, and the size of the individual abscesses was substantially smaller in the vaccinated animals. Based on the quantity of bacteria in the kidneys it was postulated that the vaccination increased the clearance of bacteria.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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