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  • EDTA anticoagulated blood  (1)
  • Interferon-alpha  (1)
  • Lysozyme  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Myelomonozytäre Leukämie: Klinische, zytologische und zytogenetische Studien bei akuten, subakuten und chronischen Verlaufsformen (1977)
    Springer
    Annals of hematology 35 (1977), S. 21-34 
    Details
    ISSN: 1432-0584
    Keywords: Myelomonocytic ; Subacute and chronic leukemia ; Bone marrow cytogenetics and cytochemistry ; Lysozyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 44 patients suffering from myelomonocytic leukemia (MML) have been observed over the last four years. They have been subclassified in acute myelomonocytic and acute monoblastic leukemias (AMML, n = 12; AMoL, n = 10), subacute myelomonocytic leukemias (SMML, n = 13), and chronic myelomonocytic leukemias (CMML, n = 9) on the basis of bone marrow cytology(blast and promonocyte counts, maturation of granulopoesis) and cytochemical findings (peroxydase and unspecific esterase reaction). This subclassification has been proved to be of prognostic relevance by its good correlation with the mean survival times (AMML: 4.5 months, AMoL: 2.4 months, SMML: 8 months, CMML: 18 months). The acute forms have been treated in general with combined cytostatic chemotherapy, whereas SMML and CMML have been treated this way only in case of progression to an acute phase. These progressions to an AMML have been observed more often and earlier in subacute forms than in chronic forms. The diagnosis of SMML and CMML is supported by the finding of sea-blue histiocytes in the bone marrow, increased lysozyme levels in serum and urine and by the absence of the Philadelphia-Chromosome.
    Notes: Zusammenfassung 44 Patienten mit myelomonozytärer Leukämie (MML) wurden während der letzten vier Jahre beobachtet. Eine Einteilung in akute myelomonozytäre und akute monoblastäre Leukämien (AMML, n = 12; AMoL, n = 10), subakute myelomonozytäre Leukämien (SMML, n = 13) und chronische myelomonozytäre Leukämien (CMML, n = 9) wurde aufgrund der Knochenmarkzytologie (Blasten- und Promonozytenanteil, Ausreifung der Granulopoese) und zytochemischer Befunde (Peroxydase- und unspezifische Esterase-Reaktion) vorgenommen. Diese Einteilung erwies sich als prognostisch relevant durch eine gute Korrelation mit den mittleren Überlebenszeiten (AMML: 4,5 Monate, AMoL: 2,4 Monate, SMML: 8 Monate, CMML: 18 Monate). Die akuten Verlaufsformen wurden in der Regel kombiniert zytostatisch behandelt, während SMML und CMML nur beim Übergang in eine akute Phase zytostatisch therapiert wurden. Derartige Übergänge in AMML wurden bei den subakuten Verlaufsformen häufiger und eher als bei den chronischen beobachtet. Zur Diagnose SMML, CMML trägt das Vorkommen seeblauer Histiozyten im Knochenmark, eine Lysozymerhöhung in Serum und Urin und das Fehlen des Philadelphia-Chromosoms bei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01006961
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  • 2
    Electronic Resource
    Electronic Resource
    Randomized study on the treatment of chronic myeloid leukemia (CML) in chronic phase with busulfan versus hydroxyurea versus interferon-alpha (1988)
    Springer
    Annals of hematology 56 (1988), S. 87-91 
    Details
    ISSN: 1432-0584
    Keywords: CML ; Busulfan ; Hydroxyurea ; Interferon-alpha ; Duration of chronic phase ; Prospective study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For palliative therapy during the chronic phase of CML busulfan has proved to be the drug of choice. During the past years hydroxyurea and also interferon-alpha have gained increasing significance since they might prolong the duration of the chronic phase. In a multicenter study it is being determined, whether the use of hydroxyurea or of interferon-alpha instead of busulfan prolongs the duration of the chronic phase of Philadelphia positive CML. Additional goals are the examination of whether the types of disease evolution and the terminal phases differ between the treatment groups, and the prospective recognition of prognostic criteria for the duration of the chronic phase of CML. By December 31, 1987, 326 CML-patients had been randomized, 150 for busulfan, 150 for hydroxyurea and 26 for interferon-alpha. The average age is 50 years. 59 patients reached the end of the chronic phase, 55 died. The mean observation time of all patients is 1.34 years. At present no significant difference in survival is recognizable between the busulfan and hydroxyurea groups. Fewer adverse effects have been observed in the hydroxyurea group. Philadelphia chromosome negative patients show a higher average age and tend to have lower white blood cell and platelet counts. The number of patients having received interferon-alpha is still too small to allow evaluation. This report intends to document organization and progress of this study which to our knowledge is, at present, the largest ongoing prospective multicenter study on the therapy of CML.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00633471
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Granulocyten-Plättchen-Rosetten („Plättchen-Satelliten“) als Ursache einer scheinbaren Thrombocytopenie (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 343-345 
    Details
    ISSN: 1432-1440
    Keywords: EDTA anticoagulated blood ; capillary blood ; blood platelets ; platelet phagocytosis ; thrombocytopenia ; polymorphonuclear leukocytes ; EDTA-Blut ; Capillarblut ; Thrombocyten ; Thrombocytenphagocytose ; Thrombocytopenie ; neutrophile Granulocyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei zwei Patienten fiel im EDTA-Blutausstrich eine außergewöhnliche Adhärenz von Blutplättchen an Granulocyten auf. In den gleichen Blutproben wurden verminderte Thrombocytenwerte gezählt. Diese Granulocyten-Plättchen-Rosetten treten sehr selten, nur in vitro im EDTA-Blut und an neutrophilen Granulocyten auf. Eine Plättchenphagocytose durch Granulocyten konnte nachgewiesen werden. Die auslösende Ursache ist unbekannt. Zur Vermeidung eines falschen Thrombocytopenie-Befundes sollte bei Beobachtung von Granulocyten-Plättchen-Rosetten eine Kontrolle der Thrombocytenzahl im Capillarblut herangezogen werden.
    Notes: Summary Extraordinary platelet adherence to polymorphonuclear leukocytes was seen in EDTA anticoagulated blood smears of two patients. From the same blood samples platelets were greatly reduced in number. Platelet satellitism (granulocyte platelet rosettes) is a rare phenomenon in vitro, only seen in EDTA anticoagulated blood, and the platelets surrounded polymorphonuclear leukocytes only. Phagocytosis of platelets was also observed. The cause of platelet satellitism is unknown. Capillary blood should be investigated in order to prevent a false thrombocytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469063
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    Paper (German National Licenses)
    Fulltext
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